Iron overload as a risk factor for hepatic ischemia‐reperfusion injury in liver transplantation: Potential role of ferroptosis

Hepatic ischemia‐reperfusion (I/R) injury is a major problem in liver transplantation (LT). Although hepatocyte cell death is the initial event in hepatic I/R injury, the underlying mechanism remains unclear. In the present study, we retrospectively analyzed the clinical data of 202 pediatric living...

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Bibliographic Details
Published in:	American journal of transplantation Vol. 20; no. 6; pp. 1606 - 1618
Main Authors:	Yamada, Naoya, Karasawa, Tadayoshi, Wakiya, Taiichi, Sadatomo, Ai, Ito, Homare, Kamata, Ryo, Watanabe, Sachiko, Komada, Takanori, Kimura, Hiroaki, Sanada, Yukihiro, Sakuma, Yasunaru, Mizuta, Koichi, Ohno, Nobuhiko, Sata, Naohiro, Takahashi, Masafumi
Format:	Journal Article
Language:	English
Published:	United States Elsevier Limited 01.06.2020 Elsevier
Subjects:	Animal models Animals Apoptosis Cell death Chelation Child Deferoxamine Ferritin Ferroptosis Homeostasis Humans Inflammation Iron Iron Overload - etiology Ischemia Lipid peroxidation Liver Liver transplantation Liver Transplantation - adverse effects liver transplantation/hepatology liver transplantation: living donor Liver transplants Mice Pediatrics Reperfusion Reperfusion Injury - etiology Retrospective Studies Risk Factors translational research/science Vitamin E liver transplantation: living donor translational research/science cell death liver transplantation/hepatology
ISSN:	1600-6135, 1600-6143, 1600-6143
Online Access:	Get full text
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