Metabolic Reprogramming at the Edge of Redox: Connections Between Metabolic Reprogramming and Cancer Redox State

The importance of redox systems as fundamental elements in biology is now widely recognized across diverse fields, from ecology to cellular biology. Their connection to metabolism is particularly significant, as it plays a critical role in energy regulation and distribution within organisms. Over re...

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Vydáno v:	International journal of molecular sciences Ročník 26; číslo 2; s. 498
Hlavní autoři:	Serrano, José J., Medina, Miguel Ángel
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Switzerland MDPI AG 09.01.2025 MDPI
Témata:	Amino acids Animals Breast cancer Cancer Carbon Cellular Reprogramming Citric Acid Cycle Dehydrogenases Development and progression Energy Metabolism Enzymes Epigenetic inheritance Genetic aspects Glucose Glucose metabolism Glycolysis Homeostasis Humans Hypoxia Kinases Leukemia Metabolic Networks and Pathways Metabolic Reprogramming Metabolism Metabolites Mitochondria Neoplasms - genetics Neoplasms - metabolism Neoplasms - pathology Oxidation-Reduction Oxidative stress Phase transitions Phosphorylation Physiological aspects Reactive oxygen species Review Roles Tumors Spain feedback reprogramming cancer metabolism emergence redox
ISSN:	1422-0067, 1661-6596, 1422-0067
On-line přístup:	Získat plný text
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Shrnutí:	The importance of redox systems as fundamental elements in biology is now widely recognized across diverse fields, from ecology to cellular biology. Their connection to metabolism is particularly significant, as it plays a critical role in energy regulation and distribution within organisms. Over recent decades, metabolism has emerged as a relevant focus in studies of biological regulation, especially following its recognition as a hallmark of cancer. This shift has broadened cancer research beyond strictly genetic perspectives. The interaction between metabolism and redox systems in carcinogenesis involves the regulation of essential metabolic pathways, such as glycolysis and the Krebs cycle, as well as the involvement of redox-active components like specific amino acids and cofactors. The feedback mechanisms linking redox systems and metabolism in cancer highlight the development of redox patterns that enhance the flexibility and adaptability of tumor processes, influencing larger-scale biological phenomena such as circadian rhythms and epigenetics.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Review-3 content type line 23
ISSN:	1422-0067 1661-6596 1422-0067
DOI:	10.3390/ijms26020498