Metabolic Reprogramming at the Edge of Redox: Connections Between Metabolic Reprogramming and Cancer Redox State

The importance of redox systems as fundamental elements in biology is now widely recognized across diverse fields, from ecology to cellular biology. Their connection to metabolism is particularly significant, as it plays a critical role in energy regulation and distribution within organisms. Over re...

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Veröffentlicht in:International journal of molecular sciences Jg. 26; H. 2; S. 498
Hauptverfasser: Serrano, José J., Medina, Miguel Ángel
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Switzerland MDPI AG 09.01.2025
MDPI
Schlagworte:
Amino acids
Animals
Breast cancer
Cancer
Carbon
Cellular Reprogramming
Citric Acid Cycle
Dehydrogenases
Development and progression
Energy Metabolism
Enzymes
Epigenetic inheritance
Genetic aspects
Glucose
Glucose metabolism
Glycolysis
Homeostasis
Humans
Hypoxia
Kinases
Leukemia
Metabolic Networks and Pathways
Metabolic Reprogramming
Metabolism
Metabolites
Mitochondria
Neoplasms - genetics
Neoplasms - metabolism
Neoplasms - pathology
Oxidation-Reduction
Oxidative stress
Phase transitions
Phosphorylation
Physiological aspects
Reactive oxygen species
Review
Roles
Tumors
Spain
feedback
reprogramming
cancer
metabolism
emergence
redox
ISSN:1422-0067, 1661-6596, 1422-0067
Online-Zugang:Volltext
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Zusammenfassung:The importance of redox systems as fundamental elements in biology is now widely recognized across diverse fields, from ecology to cellular biology. Their connection to metabolism is particularly significant, as it plays a critical role in energy regulation and distribution within organisms. Over recent decades, metabolism has emerged as a relevant focus in studies of biological regulation, especially following its recognition as a hallmark of cancer. This shift has broadened cancer research beyond strictly genetic perspectives. The interaction between metabolism and redox systems in carcinogenesis involves the regulation of essential metabolic pathways, such as glycolysis and the Krebs cycle, as well as the involvement of redox-active components like specific amino acids and cofactors. The feedback mechanisms linking redox systems and metabolism in cancer highlight the development of redox patterns that enhance the flexibility and adaptability of tumor processes, influencing larger-scale biological phenomena such as circadian rhythms and epigenetics.
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ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms26020498