Advances in Stem Cell-Based Therapies in the Treatment of Osteoarthritis

Osteoarthritis (OA) is a chronic, degenerative joint disease presenting a significant global health threat. While current therapeutic approaches primarily target symptom relief, their efficacy in repairing joint damage remains limited. Recent research has highlighted mesenchymal stem cells (MSCs) as...

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Vydáno v:International journal of molecular sciences Ročník 25; číslo 1; s. 394
Hlavní autoři: Chen, Ye, Cheng, Rui-Juan, Wu, Yinlan, Huang, Deying, Li, Yanhong, Liu, Yi
Médium: Journal Article
Jazyk:angličtina
Vydáno: Switzerland MDPI AG 28.12.2023
MDPI
Témata:
Adalimumab
Analgesics
Apoptosis
Arthritis
B cells
Biocompatible Materials
Biological products
Bone marrow
Cartilage
Cytokines
Fibroblasts
Gene Editing
Genome editing
Growth factors
Health aspects
Homeostasis
Humans
Inflammation
Kinases
Li, Robin
Medical research
Mesenchymal Stem Cells
Metabolic disorders
Osteoarthritis
Osteoarthritis - therapy
Pain
Physical therapy
Proteins
Quality of life
Review
Senescence
Stem cell research
Stem Cell Transplantation
Stem cells
Tissue engineering
Transplantation
Umbilical cord
extracellular vesicle
mesenchymal stem cells
osteoarthritis
therapy
ISSN:1422-0067, 1661-6596, 1422-0067
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Popis
Shrnutí:Osteoarthritis (OA) is a chronic, degenerative joint disease presenting a significant global health threat. While current therapeutic approaches primarily target symptom relief, their efficacy in repairing joint damage remains limited. Recent research has highlighted mesenchymal stem cells (MSCs) as potential contributors to cartilage repair, anti-inflammatory modulation, and immune regulation in OA patients. Notably, MSCs from different sources and their derivatives exhibit variations in their effectiveness in treating OA. Moreover, pretreatment and gene editing techniques of MSCs can enhance their therapeutic outcomes in OA. Additionally, the combination of novel biomaterials with MSCs has shown promise in facilitating the repair of damaged cartilage. This review summarizes recent studies on the role of MSCs in the treatment of OA, delving into their advantages and exploring potential directions for development, with the aim of providing fresh insights for future research in this critical field.
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These authors contributed equally to this work.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms25010394