Investigating Vα7.2+/CD161− T Cell and MAIT Cell Profiles Using Flow Cytometry in Healthy Subjects and Subjects with Atopic Dermatitis
This study investigates the roles of mucosal-associated invariant T (MAIT) cells and Vα7.2+/CD161− T cells in skin diseases, focusing on atopic dermatitis. MAIT cells, crucial for bridging innate and adaptive immunity, were analyzed alongside Vα7.2+/CD161− T cells in peripheral blood samples from 14...
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| Veröffentlicht in: | International journal of molecular sciences Jg. 25; H. 6; S. 3486 |
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| Abstract | This study investigates the roles of mucosal-associated invariant T (MAIT) cells and Vα7.2+/CD161− T cells in skin diseases, focusing on atopic dermatitis. MAIT cells, crucial for bridging innate and adaptive immunity, were analyzed alongside Vα7.2+/CD161− T cells in peripheral blood samples from 14 atopic dermatitis patients and 10 healthy controls. Flow cytometry and machine learning algorithms were employed for a comprehensive analysis. The results indicate a significant decrease in MAIT cells and CD69 subsets in atopic dermatitis, coupled with elevated CD38 and polyfunctional MAIT cells producing TNFα and Granzyme B (TNFα+/GzB+). Vα7.2+/CD161− T cells in atopic dermatitis exhibited a decrease in CD8 and IFNγ-producing subsets but an increase in CD38 activated and IL-22-producing subsets. These results highlight the distinctive features of MAIT cells and Vα7.2+/CD161− T cells and their different roles in the pathogenesis of atopic dermatitis and provide insights into their potential roles in immune-mediated skin diseases. |
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| AbstractList | This study investigates the roles of mucosal-associated invariant T (MAIT) cells and Vα7.2+/CD161− T cells in skin diseases, focusing on atopic dermatitis. MAIT cells, crucial for bridging innate and adaptive immunity, were analyzed alongside Vα7.2+/CD161− T cells in peripheral blood samples from 14 atopic dermatitis patients and 10 healthy controls. Flow cytometry and machine learning algorithms were employed for a comprehensive analysis. The results indicate a significant decrease in MAIT cells and CD69 subsets in atopic dermatitis, coupled with elevated CD38 and polyfunctional MAIT cells producing TNFα and Granzyme B (TNFα+/GzB+). Vα7.2+/CD161− T cells in atopic dermatitis exhibited a decrease in CD8 and IFNγ-producing subsets but an increase in CD38 activated and IL-22-producing subsets. These results highlight the distinctive features of MAIT cells and Vα7.2+/CD161− T cells and their different roles in the pathogenesis of atopic dermatitis and provide insights into their potential roles in immune-mediated skin diseases. This study investigates the roles of mucosal-associated invariant T (MAIT) cells and Vα7.2+/CD161- T cells in skin diseases, focusing on atopic dermatitis. MAIT cells, crucial for bridging innate and adaptive immunity, were analyzed alongside Vα7.2+/CD161- T cells in peripheral blood samples from 14 atopic dermatitis patients and 10 healthy controls. Flow cytometry and machine learning algorithms were employed for a comprehensive analysis. The results indicate a significant decrease in MAIT cells and CD69 subsets in atopic dermatitis, coupled with elevated CD38 and polyfunctional MAIT cells producing TNFα and Granzyme B (TNFα+/GzB+). Vα7.2+/CD161- T cells in atopic dermatitis exhibited a decrease in CD8 and IFNγ-producing subsets but an increase in CD38 activated and IL-22-producing subsets. These results highlight the distinctive features of MAIT cells and Vα7.2+/CD161- T cells and their different roles in the pathogenesis of atopic dermatitis and provide insights into their potential roles in immune-mediated skin diseases.This study investigates the roles of mucosal-associated invariant T (MAIT) cells and Vα7.2+/CD161- T cells in skin diseases, focusing on atopic dermatitis. MAIT cells, crucial for bridging innate and adaptive immunity, were analyzed alongside Vα7.2+/CD161- T cells in peripheral blood samples from 14 atopic dermatitis patients and 10 healthy controls. Flow cytometry and machine learning algorithms were employed for a comprehensive analysis. The results indicate a significant decrease in MAIT cells and CD69 subsets in atopic dermatitis, coupled with elevated CD38 and polyfunctional MAIT cells producing TNFα and Granzyme B (TNFα+/GzB+). Vα7.2+/CD161- T cells in atopic dermatitis exhibited a decrease in CD8 and IFNγ-producing subsets but an increase in CD38 activated and IL-22-producing subsets. These results highlight the distinctive features of MAIT cells and Vα7.2+/CD161- T cells and their different roles in the pathogenesis of atopic dermatitis and provide insights into their potential roles in immune-mediated skin diseases. This study investigates the roles of mucosal-associated invariant T (MAIT) cells and Vα7.2 /CD161 T cells in skin diseases, focusing on atopic dermatitis. MAIT cells, crucial for bridging innate and adaptive immunity, were analyzed alongside Vα7.2 /CD161 T cells in peripheral blood samples from 14 atopic dermatitis patients and 10 healthy controls. Flow cytometry and machine learning algorithms were employed for a comprehensive analysis. The results indicate a significant decrease in MAIT cells and CD69 subsets in atopic dermatitis, coupled with elevated CD38 and polyfunctional MAIT cells producing TNFα and Granzyme B (TNFα /GzB ). Vα7.2 /CD161 T cells in atopic dermatitis exhibited a decrease in CD8 and IFNγ-producing subsets but an increase in CD38 activated and IL-22-producing subsets. These results highlight the distinctive features of MAIT cells and Vα7.2 /CD161 T cells and their different roles in the pathogenesis of atopic dermatitis and provide insights into their potential roles in immune-mediated skin diseases. This study investigates the roles of mucosal-associated invariant T (MAIT) cells and Vα7.2[sup.+]/CD161[sup.−] T cells in skin diseases, focusing on atopic dermatitis. MAIT cells, crucial for bridging innate and adaptive immunity, were analyzed alongside Vα7.2[sup.+]/CD161[sup.−] T cells in peripheral blood samples from 14 atopic dermatitis patients and 10 healthy controls. Flow cytometry and machine learning algorithms were employed for a comprehensive analysis. The results indicate a significant decrease in MAIT cells and CD69 subsets in atopic dermatitis, coupled with elevated CD38 and polyfunctional MAIT cells producing TNFα and Granzyme B (TNFα[sup.+]/GzB[sup.+]). Vα7.2[sup.+]/CD161[sup.−] T cells in atopic dermatitis exhibited a decrease in CD8 and IFNγ-producing subsets but an increase in CD38 activated and IL-22-producing subsets. These results highlight the distinctive features of MAIT cells and Vα7.2[sup.+]/CD161[sup.−] T cells and their different roles in the pathogenesis of atopic dermatitis and provide insights into their potential roles in immune-mediated skin diseases. |
| Audience | Academic |
| Author | Gaspar, Krisztian Sajtos, Laszlo Szegedi, Andrea Singh, Parvind Barath, Sandor Hevessy, Zsuzsanna |
| AuthorAffiliation | 2 Department of Dermatology and Venereology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary; gaspar.krisztian@med.unideb.hu (K.G.); aszegedi@med.unideb.hu (A.S.); sajtos.laszlo@med.unideb.hu (L.S.) 1 Department of Laboratory Medicine, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary; parvind.singh@med.unideb.hu (P.S.); barath.sandor@med.unideb.hu (S.B.) |
| AuthorAffiliation_xml | – name: 2 Department of Dermatology and Venereology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary; gaspar.krisztian@med.unideb.hu (K.G.); aszegedi@med.unideb.hu (A.S.); sajtos.laszlo@med.unideb.hu (L.S.) – name: 1 Department of Laboratory Medicine, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary; parvind.singh@med.unideb.hu (P.S.); barath.sandor@med.unideb.hu (S.B.) |
| Author_xml | – sequence: 1 givenname: Parvind surname: Singh fullname: Singh, Parvind – sequence: 2 givenname: Krisztian surname: Gaspar fullname: Gaspar, Krisztian – sequence: 3 givenname: Andrea orcidid: 0000-0003-2109-9014 surname: Szegedi fullname: Szegedi, Andrea – sequence: 4 givenname: Laszlo surname: Sajtos fullname: Sajtos, Laszlo – sequence: 5 givenname: Sandor surname: Barath fullname: Barath, Sandor – sequence: 6 givenname: Zsuzsanna orcidid: 0000-0002-7364-9906 surname: Hevessy fullname: Hevessy, Zsuzsanna |
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| Keywords | atopic dermatitis dimensionality reduction flow cytometry unsupervised clustering Vα7.2+/CD161− T cells MAIT cells |
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| Snippet | This study investigates the roles of mucosal-associated invariant T (MAIT) cells and Vα7.2+/CD161− T cells in skin diseases, focusing on atopic dermatitis.... This study investigates the roles of mucosal-associated invariant T (MAIT) cells and Vα7.2 /CD161 T cells in skin diseases, focusing on atopic dermatitis. MAIT... This study investigates the roles of mucosal-associated invariant T (MAIT) cells and Vα7.2[sup.+]/CD161[sup.−] T cells in skin diseases, focusing on atopic... This study investigates the roles of mucosal-associated invariant T (MAIT) cells and Vα7.2+/CD161- T cells in skin diseases, focusing on atopic dermatitis.... |
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| SubjectTerms | Antigens Atopic dermatitis B cells Dendritic cells Dermatitis Dermatitis, Atopic Development and progression Disease Ethylenediaminetetraacetic acid Flow Cytometry Healthy Volunteers Humans Inflammation Investigations Lymphocytes Medical equipment and supplies industry Medical test kit industry Mucosal-Associated Invariant T Cells Pathogenesis Skin T cell receptors T cells Tumor Necrosis Factor-alpha Tumor necrosis factor-TNF |
| Title | Investigating Vα7.2+/CD161− T Cell and MAIT Cell Profiles Using Flow Cytometry in Healthy Subjects and Subjects with Atopic Dermatitis |
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