Cerebral small vessel disease and the risk of dementia: A systematic review and meta-analysis of population-based evidence

Cerebral small vessel disease is increasingly linked to dementia. We systematically searched Medline, Embase, and Cochrane databases for prospective population-based studies addressing associations of white matter hyperintensities, covert brain infarcts (i.e., clinically silent infarcts), and cerebr...

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Bibliographic Details
Published in:Alzheimer's & dementia Vol. 14; no. 11; p. 1482
Main Authors: Bos, Daniel, Wolters, Frank J, Darweesh, Sirwan K L, Vernooij, Meike W, de Wolf, Frank, Ikram, M Arfan, Hofman, Albert
Format: Journal Article
Language:English
Published: United States 01.11.2018
Subjects:
Cerebral Small Vessel Diseases - epidemiology
Dementia - epidemiology
Humans
Risk
White matter hyperintensities
Microbleeds
Imaging
Cerebral small vessel disease
Covert brain infarcts
Dementia
ISSN:1552-5279, 1552-5279
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Summary:Cerebral small vessel disease is increasingly linked to dementia. We systematically searched Medline, Embase, and Cochrane databases for prospective population-based studies addressing associations of white matter hyperintensities, covert brain infarcts (i.e., clinically silent infarcts), and cerebral microbleeds with risk of all-dementia or Alzheimer's disease and performed meta-analyses. We identified 11 studies on white matter hyperintensities, covert brain infarcts, or cerebral microbleeds with risk of all-dementia or Alzheimer's disease. Pooled analyses showed an association of white matter hyperintensity volume and a borderline association of covert brain infarcts with risk of all-dementia (hazard ratio: 1.39 [95% confidence interval: 1.00; 1.94], N = 3913, and 1.47 [95% confidence interval: 0.97; 2.22], N = 8296). Microbleeds were not statistically significantly associated with an increased risk of all-dementia (hazard ratio: 1.25 [95% confidence interval: 0.66; 2.38], N = 8739). White matter hyperintensities are associated with an increased risk of all-dementia and Alzheimer's disease in the general population. However, studies are warranted to further determine the role of markers of cerebral small vessel disease in dementia.
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ISSN:1552-5279
1552-5279
DOI:10.1016/j.jalz.2018.04.007