Understanding the FLASH effect to unravel the potential of ultra-high dose rate irradiation

A reemergence of research implementing radiation delivery at ultra-high dose rates (UHDRs) has triggered intense interest in the radiation sciences and has opened a new field of investigation in radiobiology. Much of the promise of UHDR irradiation involves the FLASH effect, an in vivo biological re...

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Bibliographic Details
Published in:International journal of radiation biology Vol. 98; no. 3; pp. 506 - 516
Main Authors: Kacem, Houda, Almeida, Aymeric, Cherbuin, Nicolas, Vozenin, Marie-Catherine
Format: Journal Article
Language:English
Published: England Taylor & Francis 04.03.2022
Subjects:
Clinical Protocols
FLASH-RT
Humans
Neoplasms - radiotherapy
Photons
plasmid
pre-clinical models
Radiation Oncology
Radiobiology
Radiotherapy Dosage
ROS
Ultra-high dose rate
plasmid
Ultra-high dose rate
FLASH-RT
pre-clinical models
ROS
ISSN:0955-3002, 1362-3095, 1362-3095
Online Access:Get full text
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Summary:A reemergence of research implementing radiation delivery at ultra-high dose rates (UHDRs) has triggered intense interest in the radiation sciences and has opened a new field of investigation in radiobiology. Much of the promise of UHDR irradiation involves the FLASH effect, an in vivo biological response observed to maintain anti-tumor efficacy without the normal tissue complications associated with standard dose rates. The FLASH effect has been validated primarily, using intermediate energy electron beams able to deliver high doses (>7 Gy) in a very short period of time (<200 ms), but has also been found with photon and proton beams. The clinical implications of this new area of research are highly significant, as FLASH radiotherapy (FLASH-RT) has the potential to enhance the therapeutic index, opening new possibilities for eradicating radio-resistant tumors without toxicity. As pioneers in this field, our group has developed a multidisciplinary research team focused on investigating the mechanisms and clinical translation of the FLASH effect. Here, we review the field of UHDR, from the physico-chemical to the biological mechanisms.
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ISSN:0955-3002
1362-3095
1362-3095
DOI:10.1080/09553002.2021.2004328