Understanding the FLASH effect to unravel the potential of ultra-high dose rate irradiation

A reemergence of research implementing radiation delivery at ultra-high dose rates (UHDRs) has triggered intense interest in the radiation sciences and has opened a new field of investigation in radiobiology. Much of the promise of UHDR irradiation involves the FLASH effect, an in vivo biological re...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:International journal of radiation biology Ročník 98; číslo 3; s. 506 - 516
Hlavní autoři: Kacem, Houda, Almeida, Aymeric, Cherbuin, Nicolas, Vozenin, Marie-Catherine
Médium: Journal Article
Jazyk:angličtina
Vydáno: England Taylor & Francis 04.03.2022
Témata:
Clinical Protocols
FLASH-RT
Humans
Neoplasms - radiotherapy
Photons
plasmid
pre-clinical models
Radiation Oncology
Radiobiology
Radiotherapy Dosage
ROS
Ultra-high dose rate
plasmid
Ultra-high dose rate
FLASH-RT
pre-clinical models
ROS
ISSN:0955-3002, 1362-3095, 1362-3095
On-line přístup:Získat plný text
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
Popis
Shrnutí:A reemergence of research implementing radiation delivery at ultra-high dose rates (UHDRs) has triggered intense interest in the radiation sciences and has opened a new field of investigation in radiobiology. Much of the promise of UHDR irradiation involves the FLASH effect, an in vivo biological response observed to maintain anti-tumor efficacy without the normal tissue complications associated with standard dose rates. The FLASH effect has been validated primarily, using intermediate energy electron beams able to deliver high doses (>7 Gy) in a very short period of time (<200 ms), but has also been found with photon and proton beams. The clinical implications of this new area of research are highly significant, as FLASH radiotherapy (FLASH-RT) has the potential to enhance the therapeutic index, opening new possibilities for eradicating radio-resistant tumors without toxicity. As pioneers in this field, our group has developed a multidisciplinary research team focused on investigating the mechanisms and clinical translation of the FLASH effect. Here, we review the field of UHDR, from the physico-chemical to the biological mechanisms.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
ISSN:0955-3002
1362-3095
1362-3095
DOI:10.1080/09553002.2021.2004328