Functional network topography of the medial entorhinal cortex
The medial entorhinal cortex (MEC) creates a map of local space, based on the firing patterns of grid, head-direction (HD), border, and object-vector (OV) cells. How these cell types are organized anatomically is debated. In-depth analysis of this question requires collection of precise anatomical a...
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| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS Jg. 119; H. 7 |
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| Sprache: | Englisch |
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15.02.2022
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| Abstract | The medial entorhinal cortex (MEC) creates a map of local space, based on the firing patterns of grid, head-direction (HD), border, and object-vector (OV) cells. How these cell types are organized anatomically is debated. In-depth analysis of this question requires collection of precise anatomical and activity data across large populations of neurons during unrestrained behavior, which neither electrophysiological nor previous imaging methods fully afford. Here, we examined the topographic arrangement of spatially modulated neurons in the superficial layers of MEC and adjacent parasubiculum using miniaturized, portable two-photon microscopes, which allow mice to roam freely in open fields. Grid cells exhibited low levels of co-occurrence with OV cells and clustered anatomically, while border, HD, and OV cells tended to intermingle. These data suggest that grid cell networks might be largely distinct from those of border, HD, and OV cells and that grid cells exhibit strong coupling among themselves but weaker links to other cell types. |
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| AbstractList | The medial entorhinal cortex (MEC) creates a map of local space, based on the firing patterns of grid, head-direction (HD), border, and object-vector (OV) cells. How these cell types are organized anatomically is debated. In-depth analysis of this question requires collection of precise anatomical and activity data across large populations of neurons during unrestrained behavior, which neither electrophysiological nor previous imaging methods fully afford. Here, we examined the topographic arrangement of spatially modulated neurons in the superficial layers of MEC and adjacent parasubiculum using miniaturized, portable two-photon microscopes, which allow mice to roam freely in open fields. Grid cells exhibited low levels of co-occurrence with OV cells and clustered anatomically, while border, HD, and OV cells tended to intermingle. These data suggest that grid cell networks might be largely distinct from those of border, HD, and OV cells and that grid cells exhibit strong coupling among themselves but weaker links to other cell types. The medial entorhinal cortex (MEC) creates a map of local space, based on the firing patterns of grid, head-direction (HD), border, and object-vector (OV) cells. How these cell types are organized anatomically is debated. In-depth analysis of this question requires collection of precise anatomical and activity data across large populations of neurons during unrestrained behavior, which neither electrophysiological nor previous imaging methods fully afford. Here, we examined the topographic arrangement of spatially modulated neurons in the superficial layers of MEC and adjacent parasubiculum using miniaturized, portable two-photon microscopes, which allow mice to roam freely in open fields. Grid cells exhibited low levels of co-occurrence with OV cells and clustered anatomically, while border, HD, and OV cells tended to intermingle. These data suggest that grid cell networks might be largely distinct from those of border, HD, and OV cells and that grid cells exhibit strong coupling among themselves but weaker links to other cell types.The medial entorhinal cortex (MEC) creates a map of local space, based on the firing patterns of grid, head-direction (HD), border, and object-vector (OV) cells. How these cell types are organized anatomically is debated. In-depth analysis of this question requires collection of precise anatomical and activity data across large populations of neurons during unrestrained behavior, which neither electrophysiological nor previous imaging methods fully afford. Here, we examined the topographic arrangement of spatially modulated neurons in the superficial layers of MEC and adjacent parasubiculum using miniaturized, portable two-photon microscopes, which allow mice to roam freely in open fields. Grid cells exhibited low levels of co-occurrence with OV cells and clustered anatomically, while border, HD, and OV cells tended to intermingle. These data suggest that grid cell networks might be largely distinct from those of border, HD, and OV cells and that grid cells exhibit strong coupling among themselves but weaker links to other cell types. |
| Author | Chen, Liangyi Bonhoeffer, Tobias Moser, May-Britt Zong, Weijian Donato, Flavio Obenhaus, Horst A Jacobsen, R Irene Rose, Tobias Cheng, Heping Moser, Edvard I |
| Author_xml | – sequence: 1 givenname: Horst A surname: Obenhaus fullname: Obenhaus, Horst A email: horst.obenhaus@ntnu.no, edvard.moser@ntnu.no organization: Centre for Neural Computation, NTNU, Trondheim 7030, Norway – sequence: 2 givenname: Weijian surname: Zong fullname: Zong, Weijian organization: Centre for Neural Computation, NTNU, Trondheim 7030, Norway – sequence: 3 givenname: R Irene surname: Jacobsen fullname: Jacobsen, R Irene organization: Centre for Neural Computation, NTNU, Trondheim 7030, Norway – sequence: 4 givenname: Tobias surname: Rose fullname: Rose, Tobias organization: Institute for Experimental Epileptology and Cognition Research, University of Bonn, Bonn 53127, Germany – sequence: 5 givenname: Flavio surname: Donato fullname: Donato, Flavio organization: Biozentrum, University of Basel, Basel 4056, Switzerland – sequence: 6 givenname: Liangyi surname: Chen fullname: Chen, Liangyi organization: Beijing Academy of Artificial Intelligence, Beijing 100101, China – sequence: 7 givenname: Heping orcidid: 0000-0002-9604-6702 surname: Cheng fullname: Cheng, Heping organization: Research Unit of Mitochondria in Brain Diseases, Chinese Academy of Medical Sciences, PKU-Nanjing Institute of Translational Medicine, Nanjing 211899, China – sequence: 8 givenname: Tobias surname: Bonhoeffer fullname: Bonhoeffer, Tobias organization: Synapses-Circuit-Plasticity, Max Planck Institute of Neurobiology, Planegg-Martinsried 82152, Germany – sequence: 9 givenname: May-Britt surname: Moser fullname: Moser, May-Britt organization: Centre for Neural Computation, NTNU, Trondheim 7030, Norway – sequence: 10 givenname: Edvard I orcidid: 0000-0003-0226-5566 surname: Moser fullname: Moser, Edvard I email: horst.obenhaus@ntnu.no, edvard.moser@ntnu.no organization: Centre for Neural Computation, NTNU, Trondheim 7030, Norway |
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| Title | Functional network topography of the medial entorhinal cortex |
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