Functional network topography of the medial entorhinal cortex

The medial entorhinal cortex (MEC) creates a map of local space, based on the firing patterns of grid, head-direction (HD), border, and object-vector (OV) cells. How these cell types are organized anatomically is debated. In-depth analysis of this question requires collection of precise anatomical a...

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Published in:Proceedings of the National Academy of Sciences - PNAS Vol. 119; no. 7
Main Authors: Obenhaus, Horst A, Zong, Weijian, Jacobsen, R Irene, Rose, Tobias, Donato, Flavio, Chen, Liangyi, Cheng, Heping, Bonhoeffer, Tobias, Moser, May-Britt, Moser, Edvard I
Format: Journal Article
Language:English
Published: United States 15.02.2022
Subjects:
Animals
Brain Mapping - methods
Entorhinal Cortex - anatomy & histology
Entorhinal Cortex - physiology
Male
Mice
Microscopy - instrumentation
Miniaturization
Motor Activity
Neurons - physiology
entorhinal cortex
grid cells
two-photon microscopy
spatial coding
topography
ISSN:1091-6490, 1091-6490
Online Access:Get more information
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Summary:The medial entorhinal cortex (MEC) creates a map of local space, based on the firing patterns of grid, head-direction (HD), border, and object-vector (OV) cells. How these cell types are organized anatomically is debated. In-depth analysis of this question requires collection of precise anatomical and activity data across large populations of neurons during unrestrained behavior, which neither electrophysiological nor previous imaging methods fully afford. Here, we examined the topographic arrangement of spatially modulated neurons in the superficial layers of MEC and adjacent parasubiculum using miniaturized, portable two-photon microscopes, which allow mice to roam freely in open fields. Grid cells exhibited low levels of co-occurrence with OV cells and clustered anatomically, while border, HD, and OV cells tended to intermingle. These data suggest that grid cell networks might be largely distinct from those of border, HD, and OV cells and that grid cells exhibit strong coupling among themselves but weaker links to other cell types.
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ISSN:1091-6490
1091-6490
DOI:10.1073/pnas.2121655119