A novel method for autophagy detection in primary cells Impaired levels of macroautophagy in immunosenescent T cells

Autophagy is a conserved constitutive cellular process, responsible for the degradation of dysfunctional proteins and organelles. Autophagy plays a role in many diseases such as neurodegeneration and cancer; however, to date, conventional autophagy detection techniques are not suitable for clinical...

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Bibliographic Details
Published in:	Autophagy Vol. 8; no. 4; pp. 677 - 689
Main Authors:	Phadwal, Kanchan, Alegre-Abarrategui, Javier, Watson, Alexander Scarth, Pike, Luke, Anbalagan, Selvakumar, Hammond, Ester M., Wade-Martins, Richard, McMichael, Andrew, Klenerman, Paul, Simon, Anna Katharina
Format:	Journal Article
Language:	English
Published:	United States Taylor & Francis 01.04.2012 Landes Bioscience
Subjects:	Adult Animals Autophagy - immunology autophagy detection B-Lymphocytes - cytology B-Lymphocytes - immunology Binding Biological Assay - methods Biology Bioscience Calcium Cancer Cell Cells, Cultured Cellular Senescence - immunology Cycle HEK293 Cells Histones - metabolism Humans ImageStream immunosenescence Landes Mice Middle Aged Organogenesis PBMCs Proteins Reproducibility of Results T cells T-Lymphocytes - cytology T-Lymphocytes - immunology Toolbox
ISSN:	1554-8627, 1554-8635, 1554-8635
Online Access:	Get full text
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