Stabilization of protein-protein interactions in drug discovery

Introduction: PPIs are involved in every disease and specific modulation of these PPIs with small molecules would significantly improve our prospects of developing therapeutic agents. Both industry and academia have engaged in the identification and use of PPI inhibitors. However in comparison, the...

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Vydané v:	Expert opinion on drug discovery Ročník 12; číslo 9; s. 925 - 940
Hlavní autori:	Andrei, Sebastian A., Sijbesma, Eline, Hann, Michael, Davis, Jeremy, O'Mahony, Gavin, Perry, Matthew W. D., Karawajczyk, Anna, Eickhoff, Jan, Brunsveld, Luc, Doveston, Richard G., Milroy, Lech-Gustav, Ottmann, Christian
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	England Taylor & Francis 02.09.2017
Predmet:	Biological Products - pharmacology Chemical biology Drug Design Drug Discovery - methods druggable genome Humans medicinal chemistry Pharmaceutical Preparations - chemical synthesis Pharmaceutical Preparations - chemistry Pharmaceutical Preparations - metabolism PPI stabilization PPIs Protein Binding Protein Stability Proteins - metabolism Small Molecule Libraries small molecules tool compounds X-ray crystallography Chemical biology X-ray crystallography druggable genome tool compounds PPI stabilization medicinal chemistry small molecules PPIs
ISSN:	1746-0441, 1746-045X, 1746-045X
On-line prístup:	Získať plný text
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