Stabilization of protein-protein interactions in drug discovery

Introduction: PPIs are involved in every disease and specific modulation of these PPIs with small molecules would significantly improve our prospects of developing therapeutic agents. Both industry and academia have engaged in the identification and use of PPI inhibitors. However in comparison, the...

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Veröffentlicht in:	Expert opinion on drug discovery Jg. 12; H. 9; S. 925 - 940
Hauptverfasser:	Andrei, Sebastian A., Sijbesma, Eline, Hann, Michael, Davis, Jeremy, O'Mahony, Gavin, Perry, Matthew W. D., Karawajczyk, Anna, Eickhoff, Jan, Brunsveld, Luc, Doveston, Richard G., Milroy, Lech-Gustav, Ottmann, Christian
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England Taylor & Francis 02.09.2017
Schlagworte:	Biological Products - pharmacology Chemical biology Drug Design Drug Discovery - methods druggable genome Humans medicinal chemistry Pharmaceutical Preparations - chemical synthesis Pharmaceutical Preparations - chemistry Pharmaceutical Preparations - metabolism PPI stabilization PPIs Protein Binding Protein Stability Proteins - metabolism Small Molecule Libraries small molecules tool compounds X-ray crystallography Chemical biology X-ray crystallography druggable genome tool compounds PPI stabilization medicinal chemistry small molecules PPIs
ISSN:	1746-0441, 1746-045X, 1746-045X
Online-Zugang:	Volltext
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