Prognostic factors and predictors of sorafenib benefit in patients with hepatocellular carcinoma: Analysis of two phase III studies

[Display omitted] •Prognostic and predictive factors for survival in patients with HCC were identified.•Vascular invasion, high alpha-fetoprotein, and high neutrophil-to-lymphocyte ratio (NLR) were prognostic for poorer overall survival.•Survival benefit with sorafenib was observed across all patien...

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Bibliographic Details
Published in:	Journal of hepatology Vol. 67; no. 5; pp. 999 - 1008
Main Authors:	Bruix, Jordi, Cheng, Ann-Lii, Meinhardt, Gerold, Nakajima, Keiko, De Sanctis, Yoriko, Llovet, Josep
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01.11.2017 Elsevier Science Ltd
Subjects:	alpha-Fetoproteins - analysis Antineoplastic Agents - administration & dosage Antineoplastic Agents - adverse effects Carcinoma, Hepatocellular - blood Carcinoma, Hepatocellular - diagnosis Carcinoma, Hepatocellular - drug therapy Carcinoma, Hepatocellular - pathology Clinical trials Drug therapy Female Hepatitis C Hepatocellular carcinoma Humans Leukocyte Count - methods Liver cancer Liver diseases Liver Neoplasms - blood Liver Neoplasms - diagnosis Liver Neoplasms - drug therapy Liver Neoplasms - pathology Lymphocytes Male Medical prognosis Middle Aged Neoplasm Invasiveness Neutrophils Niacinamide - administration & dosage Niacinamide - adverse effects Niacinamide - analogs & derivatives Overall survival Patients Phenylurea Compounds - administration & dosage Phenylurea Compounds - adverse effects Placebo effect Predictive Predictive Value of Tests Prognosis Prognostic Sorafenib α-Fetoprotein Hepatocellular carcinoma Overall survival Sorafenib Prognostic Predictive
ISSN:	0168-8278, 1600-0641, 1600-0641
Online Access:	Get full text
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