Intestinal IFN-γ–producing type 1 regulatory T cells coexpress CCR5 and programmed cell death protein 1 and downregulate IL-10 in the inflamed guts of patients with inflammatory bowel disease

IL-10 is an anti-inflammatory cytokine required for intestinal immune homeostasis. It mediates suppression of T-cell responses by type 1 regulatory T (TR1) cells but is also produced by CD25+ regulatory T (Treg) cells. We aimed to identify and characterize human intestinal TR1 cells and to investiga...

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Bibliographic Details
Published in:	Journal of allergy and clinical immunology Vol. 142; no. 5; pp. 1537 - 1547.e8
Main Authors:	Alfen, Johanna Sophie, Larghi, Paola, Facciotti, Federica, Gagliani, Nicola, Bosotti, Roberto, Paroni, Moira, Maglie, Stefano, Gruarin, Paola, Vasco, Chiara Maria, Ranzani, Valeria, Frusteri, Cristina, Iseppon, Andrea, Moro, Monica, Crosti, Maria Cristina, Gatti, Stefano, Pagani, Massimiliano, Caprioli, Flavio, Abrignani, Sergio, Flavell, Richard A., Geginat, Jens
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01.11.2018 Elsevier Limited
Subjects:	Apoptosis Biopsy CCR5 protein CD25 antigen CD4 antigen Cell death Cell proliferation Cytokines Disease Flow cytometry Helper cells Homeostasis Human subjects IL-10 IL-1β IL-23 Immunoregulation Inflammatory bowel disease Inflammatory bowel diseases Interleukin 1 Interleukin 1 receptors Interleukin 10 Interleukin 23 Interleukin 7 Intestine Laboratories Lamina propria Lymphocytes Lymphocytes T PD-1 protein Phenotypes regulatory T cells Rodents Ulcerative colitis γ-Interferon Germany CD IL-7R LAG3 PMA Treg IBD FACS IL-23 IL-1R IL-10 UC Inflammatory bowel disease regulatory T cells IL-23R STAT TR1 CRC Foxp3 PD-1 DC
ISSN:	0091-6749, 1097-6825, 1097-6825
Online Access:	Get full text
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