Multiscale effects of heating and cooling on genes and gene networks

Most organisms must cope with temperature changes. This involves genes and gene networks both as subjects and agents of cellular protection, creating difficulties in understanding. Here, we study how heating and cooling affect expression of single genes and synthetic gene circuits in We discovered t...

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Vydáno v:	Proceedings of the National Academy of Sciences - PNAS Ročník 115; číslo 45; s. E10797
Hlavní autoři:	Charlebois, Daniel A, Hauser, Kevin, Marshall, Sylvia, Balázsi, Gábor
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 06.11.2018
Témata:	Adaptation, Physiological - genetics Cell Cycle Checkpoints - genetics Cold Temperature Fungal Proteins - genetics Fungal Proteins - metabolism Gene Expression Regulation, Fungal Gene Regulatory Networks Genes, Reporter Green Fluorescent Proteins - genetics Green Fluorescent Proteins - metabolism Hot Temperature Repressor Proteins - genetics Repressor Proteins - metabolism Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism Stress, Physiological Thermodynamics noise temperature feedback regulation synthetic gene circuit cellular decision
ISSN:	1091-6490, 1091-6490
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