GBR 830, an anti-OX40, improves skin gene signatures and clinical scores in patients with atopic dermatitis

GBR 830 is a humanized mAb against OX40, a costimulatory receptor on activated T cells. OX40 inhibition might have a therapeutic role in T cell–mediated diseases, including atopic dermatitis (AD). This exploratory phase 2a study investigated the safety, efficacy, and tissue effects of GBR 830 in pat...

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Bibliographic Details
Published in:	Journal of allergy and clinical immunology Vol. 144; no. 2; pp. 482 - 493.e7
Main Authors:	Guttman-Yassky, Emma, Pavel, Ana B., Zhou, Lisa, Estrada, Yeriel D., Zhang, Ning, Xu, Hui, Peng, Xiangyu, Wen, Huei-Chi, Govas, Panayiota, Gudi, Girish, CA, Vinu, Fang, Hui, Salhi, Yacine, Back, Jonathan, Reddy, Venkateshwar, Bissonnette, Robert, Maari, Catherine, Grossman, Fred, Wolff, Gerhard
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01.08.2019 Elsevier Limited
Subjects:	Adult Antibodies, Monoclonal, Humanized - administration & dosage Antibodies, Monoclonal, Humanized - adverse effects Apoptosis Atopic dermatitis biomarkers Biopsy CCL17 protein costimulation CXCL10 protein Cytokines Cytokines - immunology Dendritic cells Dermatitis Dermatitis, Atopic - drug therapy Dermatitis, Atopic - immunology Dermatitis, Atopic - pathology Eczema FDA approval Female Gene expression Gene Expression Regulation - drug effects Gene Expression Regulation - immunology Helper cells Humans Hyperplasia Hyperplasia - immunology Hyperplasia - pathology inflammation Interleukin 8 Intravenous administration Keratin Lymphocytes Lymphocytes T Male Middle Aged Monoclonal antibodies OX40 Ox40L protein Patients Population Pruritus Psoriasis Receptors, OX40 - antagonists & inhibitors Receptors, OX40 - immunology Skin Skin - immunology Skin - pathology Skin diseases TH1 TH17/TH22 TH2 trial γ-Interferon United States > US OX40 DLQI OX40L ITT trial NRS BSA EASI costimulation Atopic dermatitis inflammation hyperplasia SCORAD IGA AD TSLP biomarkers TSLPR K16 TEAE BAS TH17/TH22 TH1 Foxp3 TH2 DC T(H)17/T(H)22 T(H)1 T(H)2
ISSN:	0091-6749, 1097-6825, 1097-6825
Online Access:	Get full text
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