Blockade of the protease ADAM17 ameliorates experimental pancreatitis

Acute and chronic pancreatitis, the latter associated with fibrosis, are multifactorial inflammatory disorders and leading causes of gastrointestinal disease-related hospitalization. Despite the global health burden of pancreatitis, currently, there are no effective therapeutic agents. In this regar...

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Bibliographic Details
Published in:	Proceedings of the National Academy of Sciences - PNAS Vol. 119; no. 42; p. e2213744119
Main Authors:	Saad, Mohamed I, Weng, Teresa, Lundy, Joanne, Gearing, Linden J, West, Alison C, Harpur, Christopher M, Alanazi, Mohammad, Hodges, Christopher, Croagh, Daniel, Kumar, Beena, Sagi, Irit, Rose-John, Stefan, Jenkins, Brendan J
Format:	Journal Article
Language:	English
Published:	United States 18.10.2022
Subjects:	Acute Disease ADAM17 Protein - genetics ADAM17 Protein - metabolism Animals Carcinogens Ceruletide - toxicity Cytokines Disintegrins Endopeptidases Fibrosis Interleukin-6 - genetics Interleukin-6 - metabolism Ketones Mice Nicotine Nitrosamines Pancreatitis - drug therapy Pancreatitis - genetics Peptide Hydrolases Tumor Necrosis Factor-alpha - metabolism apoptosis ADAM17 pancreatitis ADAM17 prodomain inhibitor inflammation
ISSN:	1091-6490, 1091-6490
Online Access:	Get more information
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