Unraveling cellular pathways contributing to drug-induced liver injury by dynamical modeling

Introduction: Drug-induced liver injury (DILI) is a significant threat to human health and a major problem in drug development. It is hard to predict due to its idiosyncratic nature and which does not show up in animal trials. Hepatic adaptive stress response pathway activation is generally observed...

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Bibliographic Details
Published in:	Expert opinion on drug metabolism & toxicology Vol. 13; no. 1; pp. 5 - 17
Main Authors:	Kuijper, Isoude A., Yang, Huan, Van De Water, Bob, Beltman, Joost B.
Format:	Journal Article
Language:	English
Published:	England Taylor & Francis 02.01.2017
Subjects:	adverse outcome pathway Animals cell fate Chemical and Drug Induced Liver Injury - diagnosis Chemical and Drug Induced Liver Injury - etiology Chemical and Drug Induced Liver Injury - prevention & control death pathway Drug Design Drug induced liver injury (DILI) Drug-Related Side Effects and Adverse Reactions - diagnosis Drug-Related Side Effects and Adverse Reactions - prevention & control dynamical modeling Humans Liver - drug effects Liver - pathology Models, Theoretical ordinary differential equations Oxidative Stress - drug effects predictive toxicology Protein Unfolding stress pathway Stress, Physiological - drug effects ordinary differential equations death pathway stress pathway cell fate predictive toxicology Drug induced liver injury (DILI) adverse outcome pathway dynamical modeling
ISSN:	1742-5255, 1744-7607
Online Access:	Get full text
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