Design Parameters for Granzyme-Mediated Cytotoxic Lymphocyte Target-Cell Killing and Specificity

Cytotoxic lymphocytes are key elements of the immune system that are primarily responsible for targeting cells infected with intracellular pathogens, or cells that have become malignantly transformed. Target cells are killed mainly via lymphocyte exocytosis of specialized lysosomes containing perfor...

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Vydané v:	Biophysical journal Ročník 109; číslo 3; s. 477 - 488
Hlavní autori:	Woodsworth, Daniel J, Dunsing, Valentin, Coombs, Daniel
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 04.08.2015
Predmet:	Animals Granzymes - immunology Humans Immunological Synapses Models, Biological Perforin - immunology T-Lymphocytes, Cytotoxic - immunology
ISSN:	1542-0086
On-line prístup:	Zistit podrobnosti o prístupe
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