Design Parameters for Granzyme-Mediated Cytotoxic Lymphocyte Target-Cell Killing and Specificity

Cytotoxic lymphocytes are key elements of the immune system that are primarily responsible for targeting cells infected with intracellular pathogens, or cells that have become malignantly transformed. Target cells are killed mainly via lymphocyte exocytosis of specialized lysosomes containing perfor...

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Bibliographic Details

Published in:	Biophysical journal Vol. 109; no. 3; pp. 477 - 488
Main Authors:	Woodsworth, Daniel J, Dunsing, Valentin, Coombs, Daniel
Format:	Journal Article
Language:	English
Published:	United States 04.08.2015
Subjects:	Animals Granzymes - immunology Humans Immunological Synapses Models, Biological Perforin - immunology T-Lymphocytes, Cytotoxic - immunology
ISSN:	1542-0086
Online Access:	Get more information
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