Protein–Protein Interaction (PPI) Network of Zebrafish Oestrogen Receptors: A Bioinformatics Workflow

Protein–protein interaction (PPI) is involved in every biological process that occurs within an organism. The understanding of PPI is essential for deciphering the cellular behaviours in a particular organism. The experimental data from PPI methods have been used in constructing the PPI network. PPI...

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Vydáno v:Life (Basel, Switzerland) Ročník 12; číslo 5; s. 650
Hlavní autoři: Zainal-Abidin, Rabiatul-Adawiah, Afiqah-Aleng, Nor, Abdullah-Zawawi, Muhammad-Redha, Harun, Sarahani, Mohamed-Hussein, Zeti-Azura
Médium: Journal Article
Jazyk:angličtina
Vydáno: Switzerland MDPI AG 27.04.2022
MDPI
Témata:
Aquaculture
Bioinformatics
Biological activity
Computer programs
Crop improvement
Disease
Genes
Genomics
Hormones
Medical research
network
network analysis
oestrogen receptor
Pathogenesis
Physiology
Plant physiology
Proteins
protein–protein interaction
Receptors
Review
Signal transduction
Workflow
Zebrafish
protein–protein interaction
network analysis
oestrogen receptor
zebrafish
bioinformatics
network
ISSN:2075-1729, 2075-1729
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Shrnutí:Protein–protein interaction (PPI) is involved in every biological process that occurs within an organism. The understanding of PPI is essential for deciphering the cellular behaviours in a particular organism. The experimental data from PPI methods have been used in constructing the PPI network. PPI network has been widely applied in biomedical research to understand the pathobiology of human diseases. It has also been used to understand the plant physiology that relates to crop improvement. However, the application of the PPI network in aquaculture is limited as compared to humans and plants. This review aims to demonstrate the workflow and step-by-step instructions for constructing a PPI network using bioinformatics tools and PPI databases that can help to predict potential interaction between proteins. We used zebrafish proteins, the oestrogen receptors (ERs) to build and analyse the PPI network. Thus, serving as a guide for future steps in exploring potential mechanisms on the organismal physiology of interest that ultimately benefit aquaculture research.
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ISSN:2075-1729
2075-1729
DOI:10.3390/life12050650