NLRX1 dampens oxidative stress and apoptosis in tissue injury via control of mitochondrial activity

Mitochondrial dysfunction is the most prominent source of oxidative stress in acute and chronic kidney disease. NLRX1 is a receptor of the innate immune system that is ubiquitously expressed and localized in mitochondria. We investigated whether NLRX1 may act at the interface of metabolism and innat...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	The Journal of experimental medicine Jg. 214; H. 8; S. 2405
Hauptverfasser:	Stokman, Geurt, Kors, Lotte, Bakker, Pieter J, Rampanelli, Elena, Claessen, Nike, Teske, Gwendoline J D, Butter, Loes, van Andel, Harmen, van den Bergh Weerman, Marius A, Larsen, Per W B, Dessing, Mark C, Zuurbier, Coert J, Girardin, Stephen E, Florquin, Sandrine, Leemans, Jaklien C
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 07.08.2017
Schlagworte:	Animals Apoptosis - physiology Disease Models, Animal Humans Ischemia - physiopathology Kidney - blood supply Kidney - metabolism Kidney - physiopathology Male Mice, Inbred C57BL Mitochondria - physiology Mitochondrial Proteins - physiology Oxidative Stress - physiology Reperfusion Injury - physiopathology
ISSN:	1540-9538, 1540-9538
Online-Zugang:	Weitere Angaben
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!