NLRX1 dampens oxidative stress and apoptosis in tissue injury via control of mitochondrial activity

Mitochondrial dysfunction is the most prominent source of oxidative stress in acute and chronic kidney disease. NLRX1 is a receptor of the innate immune system that is ubiquitously expressed and localized in mitochondria. We investigated whether NLRX1 may act at the interface of metabolism and innat...

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Bibliographic Details

Published in:	The Journal of experimental medicine Vol. 214; no. 8; p. 2405
Main Authors:	Stokman, Geurt, Kors, Lotte, Bakker, Pieter J, Rampanelli, Elena, Claessen, Nike, Teske, Gwendoline J D, Butter, Loes, van Andel, Harmen, van den Bergh Weerman, Marius A, Larsen, Per W B, Dessing, Mark C, Zuurbier, Coert J, Girardin, Stephen E, Florquin, Sandrine, Leemans, Jaklien C
Format:	Journal Article
Language:	English
Published:	United States 07.08.2017
Subjects:	Animals Apoptosis - physiology Disease Models, Animal Humans Ischemia - physiopathology Kidney - blood supply Kidney - metabolism Kidney - physiopathology Male Mice, Inbred C57BL Mitochondria - physiology Mitochondrial Proteins - physiology Oxidative Stress - physiology Reperfusion Injury - physiopathology
ISSN:	1540-9538, 1540-9538
Online Access:	Get more information
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