A Review of Curcumin and Its Derivatives as Anticancer Agents

Cancer is the second leading cause of death in the world and one of the major public health problems. Despite the great advances in cancer therapy, the incidence and mortality rates of cancer remain high. Therefore, the quest for more efficient and less toxic cancer treatment strategies is still at...

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Published in:International journal of molecular sciences Vol. 20; no. 5; p. 1033
Main Authors: Tomeh, Mhd Anas, Hadianamrei, Roja, Zhao, Xiubo
Format: Journal Article
Language:English
Published: Switzerland MDPI AG 27.02.2019
MDPI
Subjects:
Androgens
Antioxidants
Apoptosis
Bioavailability
Brain cancer
Breast cancer
Cancer therapies
Carbon
Enzymes
Hydrogenation
Prostate cancer
Review
Tumors
cellular pathway
mechanism of action
delivery system
structure activity relationship
anticancer
curcumin
ISSN:1422-0067, 1661-6596, 1422-0067
Online Access:Get full text
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Summary:Cancer is the second leading cause of death in the world and one of the major public health problems. Despite the great advances in cancer therapy, the incidence and mortality rates of cancer remain high. Therefore, the quest for more efficient and less toxic cancer treatment strategies is still at the forefront of current research. Curcumin, the active ingredient of the Curcuma longa plant, has received great attention over the past two decades as an antioxidant, anti-inflammatory, and anticancer agent. In this review, a summary of the medicinal chemistry and pharmacology of curcumin and its derivatives in regard to anticancer activity, their main mechanisms of action, and cellular targets has been provided based on the literature data from the experimental and clinical evaluation of curcumin in cancer cell lines, animal models, and human subjects. In addition, the recent advances in the drug delivery systems for curcumin delivery to cancer cells have been highlighted.
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ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms20051033