Recent Progress of Development of Optogenetic Implantable Neural Probes

As a cell type-specific neuromodulation method, optogenetic technique holds remarkable potential for the realisation of advanced neuroprostheses. By genetically expressing light-sensitive proteins such as channelrhodopsin-2 (ChR2) in cell membranes, targeted neurons could be controlled by light. Thi...

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Bibliographic Details
Published in:International journal of molecular sciences Vol. 18; no. 8; p. 1751
Main Author: Zhao, Hubin
Format: Journal Article
Language:English
Published: Switzerland MDPI AG 11.08.2017
MDPI
Subjects:
Animals
Implantable Neurostimulators
Neurology
Optogenetics - instrumentation
Optogenetics - methods
Prostheses
Proteins
Review
Transplants & implants
implantable device
optogenetic stimulation
optogenetic implants
neural probes
optogenetics
ISSN:1422-0067, 1661-6596, 1422-0067
Online Access:Get full text
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Summary:As a cell type-specific neuromodulation method, optogenetic technique holds remarkable potential for the realisation of advanced neuroprostheses. By genetically expressing light-sensitive proteins such as channelrhodopsin-2 (ChR2) in cell membranes, targeted neurons could be controlled by light. This new neuromodulation technique could then be applied into extensive brain networks and be utilised to provide effective therapies for neurological disorders. However, the development of novel optogenetic implants is still a key challenge in the field. The major requirements include small device dimensions, suitable spatial resolution, high safety, and strong controllability. In this paper, I present a concise review of the significant progress that has been made towards achieving a miniaturised, multifunctional, intelligent optogenetic implant. I identify the key limitations of current technologies and discuss the possible opportunities for future development.
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ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms18081751