Recent Progress of Development of Optogenetic Implantable Neural Probes

As a cell type-specific neuromodulation method, optogenetic technique holds remarkable potential for the realisation of advanced neuroprostheses. By genetically expressing light-sensitive proteins such as channelrhodopsin-2 (ChR2) in cell membranes, targeted neurons could be controlled by light. Thi...

Celý popis

Uložené v:
Podrobná bibliografia
Vydané v:International journal of molecular sciences Ročník 18; číslo 8; s. 1751
Hlavný autor: Zhao, Hubin
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: Switzerland MDPI AG 11.08.2017
MDPI
Predmet:
Animals
Implantable Neurostimulators
Neurology
Optogenetics - instrumentation
Optogenetics - methods
Prostheses
Proteins
Review
Transplants & implants
implantable device
optogenetic stimulation
optogenetic implants
neural probes
optogenetics
ISSN:1422-0067, 1661-6596, 1422-0067
On-line prístup:Získať plný text
Tagy: Pridať tag
Žiadne tagy, Buďte prvý, kto otaguje tento záznam!
Popis
Shrnutí:As a cell type-specific neuromodulation method, optogenetic technique holds remarkable potential for the realisation of advanced neuroprostheses. By genetically expressing light-sensitive proteins such as channelrhodopsin-2 (ChR2) in cell membranes, targeted neurons could be controlled by light. This new neuromodulation technique could then be applied into extensive brain networks and be utilised to provide effective therapies for neurological disorders. However, the development of novel optogenetic implants is still a key challenge in the field. The major requirements include small device dimensions, suitable spatial resolution, high safety, and strong controllability. In this paper, I present a concise review of the significant progress that has been made towards achieving a miniaturised, multifunctional, intelligent optogenetic implant. I identify the key limitations of current technologies and discuss the possible opportunities for future development.
Bibliografia:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ObjectType-Review-3
content type line 23
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms18081751