Identification of PRKCQ-AS1 as a Keratinocyte-Derived Exosomal lncRNA That Promotes Th17 Differentiation and IL-17 secretion in Psoriasis Through Bioinformatics, Machine Learning Algorithms, and Cell Experiments

Psoriasis is an immune-mediated skin disease where Th17 cell differentiation and IL-17 secretion play critical roles. This study investigates key exosomal ncRNAs regulating the Th17/IL-17 axis in psoriasis and their mechanisms. We integrated bulk RNA sequencing datasets from the GEO database to cons...

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Bibliographic Details
Published in:	Journal of inflammation research Vol. 18; no. Issue 1; pp. 6557 - 6582
Main Authors:	Gao, Pengfei, Gao, Xiaolu, Lin, Long, Zhang, Ming, Luo, Dongqiang, Chen, Chuyan, Li, Yujie, He, Yufeng, Liu, Xianmiao, Shi, Chunyu, Yang, Ruisi
Format:	Journal Article
Language:	English
Published:	New Zealand Taylor & Francis Ltd 01.01.2025 Dove Dove Medical Press
Subjects:	Bioinformatics Biological products CD4 antigen Cell activation Cell culture Cell differentiation Cells Datasets Exosomes Gene set enrichment analysis Genes Genome-wide association studies Helper cells Immune system Immunofluorescence Infiltration Interleukin 17 Keratinocytes Learning algorithms Lymphocytes Lymphocytes T Machine learning MicroRNAs Non-coding RNA Original Research pathogenesis PRKCQ-AS1 Psoriasis Ribonucleic acid RNA Signal transduction Skin diseases Stat3 protein Th17 Transfection pathogenesis Th17 exosomes psoriasis bioinformatics PRKCQ-AS1
ISSN:	1178-7031, 1178-7031
Online Access:	Get full text
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