An unexpected role of CLASP1 in radiation response and S-phase regulation of head and neck cancer cells

Radiotherapy is a mainstay of treatment for head and neck squamous cell carcinoma (HNSCC), either definitive or adjuvant to surgery. Biological factors known to affect radiation response are hypoxia and DNA repair capacity, but several lines of evidence indicate that other genes and pathways in the...

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Bibliographic Details
Published in:	PloS one Vol. 20; no. 8; p. e0329731
Main Authors:	de Roest, Reinout H., Buijze, Marijke, Veth, Myrthe, de Lint, Klaas, Pai, Govind, Rooimans, Martin A., Wolthuis, Rob M.F., Brink, Arjen, Poell, Jos B., Brakenhoff, Ruud H.
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 06.08.2025 Public Library of Science (PLoS)
Subjects:	Biology and life sciences Cancer Cancer therapies Cell cycle Cell death Cell Line, Tumor Chromosomes CRISPR CRISPR-Cas Systems Damage detection Deoxyribonucleic acid DNA DNA damage DNA Damage - radiation effects DNA repair Functional analysis Gene Expression Regulation, Neoplastic - radiation effects Gene Knockout Techniques Genes Genomes Head & neck cancer Head and neck carcinoma Head and Neck Neoplasms - genetics Head and Neck Neoplasms - metabolism Head and Neck Neoplasms - pathology Head and Neck Neoplasms - radiotherapy Human papillomavirus Humans Hypoxia Medicine and Health Sciences Microtubule-Associated Proteins - genetics Microtubule-Associated Proteins - metabolism Mutation Physical Sciences Radiation damage Radiation therapy Radiation Tolerance - genetics Research and Analysis Methods S Phase - genetics S Phase - radiation effects Squamous cell carcinoma Squamous Cell Carcinoma of Head and Neck - genetics Toxicity Tumor cells Tumors
ISSN:	1932-6203, 1932-6203
Online Access:	Get full text
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