Fatty Acid Diets: Regulation of Gut Microbiota Composition and Obesity and Its Related Metabolic Dysbiosis

Long-term high-fat dietary intake plays a crucial role in the composition of gut microbiota in animal models and human subjects, which affect directly short-chain fatty acid (SCFA) production and host health. This review aims to highlight the interplay of fatty acid (FA) intake and gut microbiota co...

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Veröffentlicht in:International journal of molecular sciences Jg. 21; H. 11; S. 4093
Hauptverfasser: Machate, David Johane, Figueiredo, Priscila Silva, Marcelino, Gabriela, Guimarães, Rita de Cássia Avellaneda, Hiane, Priscila Aiko, Bogo, Danielle, Pinheiro, Verônica Assalin Zorgetto, Oliveira, Lincoln Carlos Silva de, Pott, Arnildo
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Switzerland MDPI AG 08.06.2020
MDPI
Schlagworte:
Animals
Cholesterol
Diabetes
Diet
Diet, High-Fat
Dysbiosis
Energy
Energy Metabolism
Fatty acids
Fatty Acids - metabolism
Fatty Acids, Unsaturated - metabolism
Fatty Acids, Volatile - metabolism
Gastrointestinal Microbiome
Gut microbiota
Health promotion
Human subjects
Humans
Inflammatory bowel disease
Insulin resistance
Metabolic Syndrome - etiology
Metabolic Syndrome - metabolism
Metabolism
Metabolites
Microbiota
Obesity
Obesity - etiology
Obesity - metabolism
Oils & fats
Polyunsaturated fatty acids
Review
health
inflammatory diseases
intestinal bacteria
short-chain fatty acids
diabetes
hypertension
ISSN:1422-0067, 1661-6596, 1422-0067
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Zusammenfassung:Long-term high-fat dietary intake plays a crucial role in the composition of gut microbiota in animal models and human subjects, which affect directly short-chain fatty acid (SCFA) production and host health. This review aims to highlight the interplay of fatty acid (FA) intake and gut microbiota composition and its interaction with hosts in health promotion and obesity prevention and its related metabolic dysbiosis. The abundance of the Bacteroidetes/Firmicutes ratio, as Actinobacteria and Proteobacteria species are associated with increased SCFA production, reported high-fat diet rich in medium-chain fatty acids (MCFAs), monounsaturated fatty acids (MUFAs), and n–3 polyunsaturated fatty acids (PUFAs) as well as low-fat diets rich in long-chain fatty acids (LCFAs). SCFAs play a key role in health promotion and prevention and, reduction and reversion of metabolic syndromes in the host. Furthermore, in this review, we discussed the type of fatty acids and their amount, including the administration time and their interplay with gut microbiota and its results about health or several metabolic dysbioses undergone by hosts.
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ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms21114093