Fructose-fed streptozotocin-injected rat: an alternative model for type 2 diabetes

The main objective of the study was to develop an alternative non-genetic rat model for type 2 diabetes (T2D). Six-week-old male Sprague-Dawley rats (190.56±23.60 g) were randomly divided into six groups, namely: Normal Control (NC), Diabetic Control (DBC), Fructose-10 (FR10), Fructose-20 (FR20), Fr...

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Bibliographic Details
Published in:	Pharmacological reports Vol. 64; no. 1; pp. 129 - 139
Main Authors:	Wilson, Rachel D., Islam, Md. Shahidul
Format:	Journal Article
Language:	English
Published:	Cham Elsevier Urban & Partner Sp. z o.o 01.01.2012 Springer International Publishing
Subjects:	animal model Animals Blood Glucose - metabolism Diabetes Mellitus, Experimental - blood Diabetes Mellitus, Experimental - chemically induced Diabetes Mellitus, Experimental - metabolism Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - metabolism Diet Disease Models, Animal Drinking Water Drug Safety and Pharmacovigilance Eating experimental diabetes fructose Fructose - administration & dosage Glucose Tolerance Test - methods Insulin - blood Insulin - metabolism Insulin Resistance - physiology Insulin-Secreting Cells - metabolism Lipids - blood Liver Glycogen - metabolism Male Pharmacotherapy Pharmacy rat Rats Rats, Sprague-Dawley streptozotocin type 2 diabetes fructose type 2 diabetes streptozotocin rat experimental diabetes animal model
ISSN:	1734-1140, 2299-5684, 2299-5684
Online Access:	Get full text
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