The genomic landscapes of inflammation

Inflammation involves the activation of a highly coordinated gene expression program that is specific for the initial stimulus and occurs in a different manner in bystander parenchymal cells and professional immune system cells recruited to the inflamed site. Recent data demonstrate that development...

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Bibliographic Details
Published in:Genes & development Vol. 25; no. 2; p. 101
Main Authors: Natoli, Gioacchino, Ghisletti, Serena, Barozzi, Iros
Format: Journal Article
Language:English
Published: United States 15.01.2011
Subjects:
Animals
Gene Expression Regulation
Genome
Humans
Inflammation - genetics
Macrophages - metabolism
Transcription Factors - metabolism
ISSN:1549-5477, 1549-5477
Online Access:Get more information
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Summary:Inflammation involves the activation of a highly coordinated gene expression program that is specific for the initial stimulus and occurs in a different manner in bystander parenchymal cells and professional immune system cells recruited to the inflamed site. Recent data demonstrate that developmental transcription factors like the macrophage fate-determining Pu.1 set the stage for the activity of ubiquitous transcription factors activated by inflammatory stimuli, like NF-kB, AP-1, and interferon regulatory factors (IRFs). The intersection of lineage-determining and stimulus-activated transcription factors at enhancers explains cell type specificity in inflammatory responses.
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ISSN:1549-5477
1549-5477
DOI:10.1101/gad.2018811