Markers of Oxidative Damage and Antioxidant Enzyme Activities as Predictors of Morbidity and Mortality in Patients With Chronic Heart Failure

Although the majority of previous findings unequivocally confirmed the existence of systemic oxidative stress in chronic heart failure (CHF) patients, data on prognostic potential of biomarkers of oxidative lipid and protein damage are limited. We aimed to address the relation of oxidative stress ma...

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Published in:	Journal of cardiac failure Vol. 18; no. 6; pp. 493 - 501
Main Authors:	Radovanovic, Slavica, Savic-Radojevic, Ana, Pljesa-Ercegovac, Marija, Djukic, Tatjana, Suvakov, Sonja, Krotin, Mirjana, Simic, Dragan V., Matic, Marija, Radojicic, Zoran, Pekmezovic, Tatjana, Simic, Tatjana
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01.06.2012
Subjects:	Aged Biomarkers - blood Cardiovascular Case-Control Studies Chronic Disease Cohort Studies Disease Progression Echocardiography Female Follow-Up Studies glutathione peroxidase Glutathione Peroxidase - blood Heart Failure - blood Heart Failure - mortality Humans Lipid Peroxidation - physiology Male malondialdehyde Malondialdehyde - blood Middle Aged Oxidative stress Oxidative Stress - physiology Oxidoreductases - blood reactive carbonyl derivatives remodeling Superoxide Dismutase - blood Ventricular Remodeling - physiology Oxidative stress remodeling reactive carbonyl derivatives malondialdehyde glutathione peroxidase
ISSN:	1071-9164, 1532-8414, 1532-8414
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Abstract	Although the majority of previous findings unequivocally confirmed the existence of systemic oxidative stress in chronic heart failure (CHF) patients, data on prognostic potential of biomarkers of oxidative lipid and protein damage are limited. We aimed to address the relation of oxidative stress markers to severity and prognosis in CHF secondary to ischemic cardiomyopathy. Plasma malondialdehyde (MDA), protein thiol groups (P-SH), reactive carbonyl derivatives (RCD), together with glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) activities were determined in 120 CHF patients and 69 healthy controls. Increased lipid peroxidation (MDA) and oxidation of plasma proteins (RCD; P-SH) s well as downregulated GSH-Px activity were found in CHF patients compared with controls. Significant correlation was obtained only for RCD content and remodeling indices (LVEDV: r = 0.469, P = .008; LVESV: r = 0.452; P = .011). Cox regression analysis demonstrated only MDA (HR = 3.33; CI: 1.55–7.12; P = .002) as independent predictor of death, whereas SOD was associated with unstable angina pectoris (HR = 2.09; CI: 1.16–3.78; P = .011). In the course of CHF progression, carbonyl stress is implicated in the LV remodeling. Malondialdehyde level might be a useful parameter for monitoring and planning management of CHF patients.
AbstractList	Although the majority of previous findings unequivocally confirmed the existence of systemic oxidative stress in chronic heart failure (CHF) patients, data on prognostic potential of biomarkers of oxidative lipid and protein damage are limited. We aimed to address the relation of oxidative stress markers to severity and prognosis in CHF secondary to ischemic cardiomyopathy. Plasma malondialdehyde (MDA), protein thiol groups (P-SH), reactive carbonyl derivatives (RCD), together with glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) activities were determined in 120 CHF patients and 69 healthy controls. Increased lipid peroxidation (MDA) and oxidation of plasma proteins (RCD; P-SH) s well as downregulated GSH-Px activity were found in CHF patients compared with controls. Significant correlation was obtained only for RCD content and remodeling indices (LVEDV: r = 0.469, P = .008; LVESV: r = 0.452; P = .011). Cox regression analysis demonstrated only MDA (HR = 3.33; CI: 1.55–7.12; P = .002) as independent predictor of death, whereas SOD was associated with unstable angina pectoris (HR = 2.09; CI: 1.16–3.78; P = .011). In the course of CHF progression, carbonyl stress is implicated in the LV remodeling. Malondialdehyde level might be a useful parameter for monitoring and planning management of CHF patients. Abstract Background Although the majority of previous findings unequivocally confirmed the existence of systemic oxidative stress in chronic heart failure (CHF) patients, data on prognostic potential of biomarkers of oxidative lipid and protein damage are limited. We aimed to address the relation of oxidative stress markers to severity and prognosis in CHF secondary to ischemic cardiomyopathy. Methods and Results Plasma malondialdehyde (MDA), protein thiol groups (P-SH), reactive carbonyl derivatives (RCD), together with glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) activities were determined in 120 CHF patients and 69 healthy controls. Increased lipid peroxidation (MDA) and oxidation of plasma proteins (RCD; P-SH) s well as downregulated GSH-Px activity were found in CHF patients compared with controls. Significant correlation was obtained only for RCD content and remodeling indices (LVEDV: r = 0.469, P = .008; LVESV: r = 0.452; P = .011). Cox regression analysis demonstrated only MDA (HR = 3.33; CI: 1.55–7.12; P = .002) as independent predictor of death, whereas SOD was associated with unstable angina pectoris (HR = 2.09; CI: 1.16–3.78; P = .011). Conclusions In the course of CHF progression, carbonyl stress is implicated in the LV remodeling. Malondialdehyde level might be a useful parameter for monitoring and planning management of CHF patients. Although the majority of previous findings unequivocally confirmed the existence of systemic oxidative stress in chronic heart failure (CHF) patients, data on prognostic potential of biomarkers of oxidative lipid and protein damage are limited. We aimed to address the relation of oxidative stress markers to severity and prognosis in CHF secondary to ischemic cardiomyopathy.BACKGROUNDAlthough the majority of previous findings unequivocally confirmed the existence of systemic oxidative stress in chronic heart failure (CHF) patients, data on prognostic potential of biomarkers of oxidative lipid and protein damage are limited. We aimed to address the relation of oxidative stress markers to severity and prognosis in CHF secondary to ischemic cardiomyopathy.Plasma malondialdehyde (MDA), protein thiol groups (P-SH), reactive carbonyl derivatives (RCD), together with glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) activities were determined in 120 CHF patients and 69 healthy controls. Increased lipid peroxidation (MDA) and oxidation of plasma proteins (RCD; P-SH) s well as downregulated GSH-Px activity were found in CHF patients compared with controls. Significant correlation was obtained only for RCD content and remodeling indices (LVEDV: r = 0.469, P = .008; LVESV: r = 0.452; P = .011). Cox regression analysis demonstrated only MDA (HR = 3.33; CI: 1.55-7.12; P = .002) as independent predictor of death, whereas SOD was associated with unstable angina pectoris (HR = 2.09; CI: 1.16-3.78; P = .011).METHODS AND RESULTSPlasma malondialdehyde (MDA), protein thiol groups (P-SH), reactive carbonyl derivatives (RCD), together with glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) activities were determined in 120 CHF patients and 69 healthy controls. Increased lipid peroxidation (MDA) and oxidation of plasma proteins (RCD; P-SH) s well as downregulated GSH-Px activity were found in CHF patients compared with controls. Significant correlation was obtained only for RCD content and remodeling indices (LVEDV: r = 0.469, P = .008; LVESV: r = 0.452; P = .011). Cox regression analysis demonstrated only MDA (HR = 3.33; CI: 1.55-7.12; P = .002) as independent predictor of death, whereas SOD was associated with unstable angina pectoris (HR = 2.09; CI: 1.16-3.78; P = .011).In the course of CHF progression, carbonyl stress is implicated in the LV remodeling. Malondialdehyde level might be a useful parameter for monitoring and planning management of CHF patients.CONCLUSIONSIn the course of CHF progression, carbonyl stress is implicated in the LV remodeling. Malondialdehyde level might be a useful parameter for monitoring and planning management of CHF patients.
Author	Suvakov, Sonja Simic, Dragan V. Simic, Tatjana Djukic, Tatjana Savic-Radojevic, Ana Radovanovic, Slavica Matic, Marija Pljesa-Ercegovac, Marija Krotin, Mirjana Radojicic, Zoran Pekmezovic, Tatjana
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Cites_doi	10.1136/heart.89.8.871 10.1586/14779072.3.4.717 10.1016/S0021-9258(17)41960-0 10.1016/S0735-1097(02)01721-7 10.1046/j.1523-1755.1999.00613.x 10.1016/S0021-9258(19)52451-6 10.1371/journal.pone.0004871 10.1152/ajpregu.00880.2006 10.1016/S0002-8703(96)90063-0 10.1172/JCI200524408 10.1136/hrt.65.5.245 10.1093/ndt/gfg020 10.1111/j.1939-1676.2005.tb02724.x 10.1253/circj.CJ-08-0014 10.1179/135100008X259204 10.1136/hrt.2005.068270 10.1016/j.yjmcc.2004.04.001 10.1001/jama.281.18.1718 10.1016/S0021-9258(19)45228-9 10.1111/j.1440-1681.2008.04923.x 10.1161/01.RES.0000033523.08033.16 10.1253/circj.CJ-08-0072 10.1113/jphysiol.2003.055913 10.1074/jbc.M110.118182 10.1016/S0894-7317(89)80014-8 10.2741/3375 10.1016/j.cardfail.2009.05.009 10.1172/JCI119076 10.1016/0076-6879(87)43013-9 10.1080/00365510260390019 10.1042/bj3240001 10.1093/eurjhf/hfp042 10.1016/j.jacc.2004.01.036 10.1161/01.CIR.0000041431.57222.AF 10.1007/s10741-006-9188-2 10.1210/me.2008-0023 10.1161/CIRCHEARTFAILURE.109.864785 10.1038/sj.jhh.1001945 10.1016/S0076-6879(94)33040-9
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Keywords	Oxidative stress remodeling reactive carbonyl derivatives malondialdehyde glutathione peroxidase
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References	Yucel, Aydoqdu, Senes, Topkaya, Nebioqlu (bib29) 2002; 62 Shao, Pennathur, Pagani, Oda, Witztum, Oram (bib28) 2010; 285 Guo, Saini, Wang, Gupta, Goyal, Dhalla (bib4) 2005; 3 Mimic-Oka, Simic, Pljesa, Stupar, Turkovic (bib15) 2001; 8 Diaz-Velez, Garcia Castineiras, Mandoza Ramos, Hernández-López (bib9) 1996; 131 Radovanovic, Krotin, Simic, Mimic-Oka, Savic-Radojevic, Pljesa-Ercegovac (bib10) 2008; 13 Schiller, Shah, Crawford, DeMaria, Devereux, Feigenbaum (bib18) 1989; 2 Dean, Fu, Stocker, Davies (bib13) 1997; 324 Giordano (bib3) 2005; 115 Long, Goldenthal, Wu, Marin-Garcia (bib7) 2004; 37 Freeman, Rush, Milbury, Blumberg (bib5) 2005; 19 Misra, Fridovich (bib22) 1972; 247 Gunzler, Kremers, Flohe (bib23) 1974; 12 de Lorgeril, Salen (bib32) 2006; 11 Eleuteri, Magno, Gnemmi, Carbone, Colombo, La Rocca (bib24) 2009; 14 Bergamini, Cicoira, Rossi, Vassanelli (bib6) 2009; 11 Halliwell, Gutteridge (bib14) 2007 Daniels, Naya, Rundell, de Tombe (bib37) 2007; 293 Belch, Bridges, Scott, Chopra (bib17) 1991; 65 Scott, Deman, Peeters, Van den Branden, Stolear (bib26) 2003; 18 Berry, Hare (bib42) 2004; 555 Nonaka-Sarukawa, Yamamoto, Aoki, Takano, Katsuki, Ikeda (bib8) 2003; 89 Tsutsui, Tsutamoto, Wada, Maeda, Mabuchi, Hayashi (bib11) 2002; 39 Levine, Williams, Stadtman, Shacter (bib19) 1994; 233 Jocelyn (bib20) 1987; 143 Masano, Kawashima, Toh, Satomi-Kobayashi, Shinohara, Takaya (bib36) 2008; 72 Qin, Lennon-Edwards, Lancel, Biolo, Siwik, Pimentel (bib39) 2010; 3 Seddon, Looi, Shah (bib1) 2007; 93 Rajagopalan, Meng, Ramasamy, Harrison, Galis (bib40) 1996; 98 Uchida, Kawakishi (bib30) 1994; 269 Ding, Brower, Zhong, Murray, Holland, Janicki (bib38) 2008; 35 Tsutsui, Kinugawa, Matsushima (bib35) 2008; 72 Holvoet, Collen, Van de Werf (bib27) 1999; 281 Simic, Mimic-Oka, Pljesa- Ercegovac, Savic-Radojevic, Opacic, Matic (bib16) 2006; 20 Landmesser, Spiekermann, Dikalov, Tatge, Wilke, Kohler (bib31) 2002; 106 Boaz, Matas, Biro (bib25) 1999; 56 Lee, Kim, Choi, Kim, Yasue, Son (bib34) 2008; 22 Damy, Kirsch, Khouzami, Caramelle, Le Corvoisier, Roudot-Thoraval (bib33) 2009; 4 Valgimigli, Merli, Malagutti, Soukhomovskaia, Cicchitelli, Antelli (bib2) 2004; 43 Charach, George, Afek, Wexler, Sheps, Keren (bib12) 2009; 15 Lowry, Rosebrough, Farr, Randall (bib21) 1951; 193 Seshiah, Weber, Rocic, Valppu, Taniyama, Griendling (bib41) 2002; 91 Guo (10.1016/j.cardfail.2012.04.003_bib4) 2005; 3 Diaz-Velez (10.1016/j.cardfail.2012.04.003_bib9) 1996; 131 Simic (10.1016/j.cardfail.2012.04.003_bib16) 2006; 20 Schiller (10.1016/j.cardfail.2012.04.003_bib18) 1989; 2 Eleuteri (10.1016/j.cardfail.2012.04.003_bib24) 2009; 14 Daniels (10.1016/j.cardfail.2012.04.003_bib37) 2007; 293 Freeman (10.1016/j.cardfail.2012.04.003_bib5) 2005; 19 Scott (10.1016/j.cardfail.2012.04.003_bib26) 2003; 18 Lee (10.1016/j.cardfail.2012.04.003_bib34) 2008; 22 Ding (10.1016/j.cardfail.2012.04.003_bib38) 2008; 35 Seshiah (10.1016/j.cardfail.2012.04.003_bib41) 2002; 91 Rajagopalan (10.1016/j.cardfail.2012.04.003_bib40) 1996; 98 Mimic-Oka (10.1016/j.cardfail.2012.04.003_bib15) 2001; 8 Boaz (10.1016/j.cardfail.2012.04.003_bib25) 1999; 56 Misra (10.1016/j.cardfail.2012.04.003_bib22) 1972; 247 Tsutsui (10.1016/j.cardfail.2012.04.003_bib11) 2002; 39 Tsutsui (10.1016/j.cardfail.2012.04.003_bib35) 2008; 72 Seddon (10.1016/j.cardfail.2012.04.003_bib1) 2007; 93 Radovanovic (10.1016/j.cardfail.2012.04.003_bib10) 2008; 13 Charach (10.1016/j.cardfail.2012.04.003_bib12) 2009; 15 Masano (10.1016/j.cardfail.2012.04.003_bib36) 2008; 72 de Lorgeril (10.1016/j.cardfail.2012.04.003_bib32) 2006; 11 Qin (10.1016/j.cardfail.2012.04.003_bib39) 2010; 3 Long (10.1016/j.cardfail.2012.04.003_bib7) 2004; 37 Damy (10.1016/j.cardfail.2012.04.003_bib33) 2009; 4 Giordano (10.1016/j.cardfail.2012.04.003_bib3) 2005; 115 Levine (10.1016/j.cardfail.2012.04.003_bib19) 1994; 233 Yucel (10.1016/j.cardfail.2012.04.003_bib29) 2002; 62 Lowry (10.1016/j.cardfail.2012.04.003_bib21) 1951; 193 Nonaka-Sarukawa (10.1016/j.cardfail.2012.04.003_bib8) 2003; 89 Dean (10.1016/j.cardfail.2012.04.003_bib13) 1997; 324 Landmesser (10.1016/j.cardfail.2012.04.003_bib31) 2002; 106 Valgimigli (10.1016/j.cardfail.2012.04.003_bib2) 2004; 43 Belch (10.1016/j.cardfail.2012.04.003_bib17) 1991; 65 Halliwell (10.1016/j.cardfail.2012.04.003_bib14) 2007 Shao (10.1016/j.cardfail.2012.04.003_bib28) 2010; 285 Berry (10.1016/j.cardfail.2012.04.003_bib42) 2004; 555 Uchida (10.1016/j.cardfail.2012.04.003_bib30) 1994; 269 Jocelyn (10.1016/j.cardfail.2012.04.003_bib20) 1987; 143 Bergamini (10.1016/j.cardfail.2012.04.003_bib6) 2009; 11 Gunzler (10.1016/j.cardfail.2012.04.003_bib23) 1974; 12 Holvoet (10.1016/j.cardfail.2012.04.003_bib27) 1999; 281
References_xml	– volume: 35 start-page: 827 year: 2008 end-page: 835 ident: bib38 article-title: Defective intracellular Ca2+ homeostasis contributes to myocyte dysfunction during ventricular remodeling induced by chronic volume overload in rats publication-title: Clin Exp Pharmacol Physiol – volume: 106 start-page: 3073 year: 2002 end-page: 3078 ident: bib31 article-title: Vascular oxidative stress and endothelial dysfunction in patients with chronic heart failure: role of xanthine-oxidase and extracellular superoxide dismutase publication-title: Circulation – volume: 37 start-page: 63 year: 2004 end-page: 70 ident: bib7 article-title: Mitochondrial Ca publication-title: J Mol Cell Cardiol – volume: 22 start-page: 2176 year: 2008 end-page: 2189 ident: bib34 article-title: Dysregulation of adipose glutathione peroxidase 3 in obesity contributes to local and systemic oxidative stress publication-title: Mol Endocrinol – volume: 72 start-page: 1512 year: 2008 end-page: 1519 ident: bib36 article-title: Beneficial effects of exogenous tetrahydrobiopterin on left ventricular remodeling after myocardial infarction in rats: the possible role of oxidative stress caused by uncoupled endothelial nitric oxide synthase publication-title: Circ J – volume: 91 start-page: 406 year: 2002 end-page: 413 ident: bib41 article-title: Angiotensin II stimulation of NAD(P)H oxidase activity: upstream mediators publication-title: Circ Res – volume: 43 start-page: 2000 year: 2004 end-page: 2008 ident: bib2 article-title: Hydroxyl radical generation, levels of tumor necrosis factor-alpha, and progression to heart failure after acute myocardial infarction publication-title: J Am Coll Cardiol – volume: 324 start-page: 1 year: 1997 end-page: 18 ident: bib13 article-title: Biochemistry and pathology of radical-mediated protein oxidation publication-title: Biochem J – volume: 20 start-page: 149 year: 2006 end-page: 155 ident: bib16 article-title: Byproducts of oxidative protein damage and antioxidant enzyme activities in plasma of patients with different degrees of essential hypertension publication-title: J Hum Hypertens – volume: 98 start-page: 2572 year: 1996 end-page: 2579 ident: bib40 article-title: Reactive oxygen species produced by macrophage-derived foam cells regulate the activity of vascular matrix metalloproteinases in vitro. Implications for atherosclerotic plaque stability publication-title: J Clin Invest – volume: 3 start-page: 306 year: 2010 end-page: 313 ident: bib39 article-title: Cardiac-specific overexpression of catalase identifies hydrogen peroxide-dependent and -independent phases of myocardial remodeling and prevents the progression to overt heart failure in G(alpha)q-overexpressing transgenic mice publication-title: Circ Heart Fail – volume: 4 start-page: e4871 year: 2009 ident: bib33 article-title: Glutathione deficiency in cardiac patients is related to the functional status and structural cardiac abnormalities publication-title: PLoS One – volume: 8 start-page: 1 year: 2001 end-page: 5 ident: bib15 article-title: Oxidative modification of plasma proteins in different stages of chronic renal failure publication-title: Facta Universitatis – volume: 131 start-page: 146 year: 1996 end-page: 152 ident: bib9 article-title: Increased malondialdehide in peripheral blood of patients with congestive heart failure publication-title: Am Heart J – start-page: 268 year: 2007 end-page: 340 ident: bib14 article-title: Measurement of reactive species publication-title: Free Radicals in Biology and Medicine – volume: 2 start-page: 358 year: 1989 end-page: 367 ident: bib18 article-title: Recommendations for quantitation of the left ventricle by two-dimensional echocardiography. American Society of Echocardiography Committee on Standards, Subcommittee on Quantitation of Two-Dimensional Echocardiograms publication-title: J Am Soc Echocardiogr – volume: 18 start-page: 737 year: 2003 end-page: 742 ident: bib26 article-title: Cardiac troponin T and malondialdehyde modified plasma lipids in haemodialysis patients publication-title: Nephrol Dial Transplant – volume: 39 start-page: 957 year: 2002 end-page: 962 ident: bib11 article-title: Plasma oxidized low-density lipoprotein as a prognostic predictor in patients with chronic congestive heart failure publication-title: J Am Coll Cardiol – volume: 293 start-page: R284 year: 2007 end-page: R292 ident: bib37 article-title: Development of contractile dysfunction in rat heart failure; hierarchy of cellular events publication-title: Am J Physiol Regul Integr Comp Physiol – volume: 193 start-page: 265 year: 1951 end-page: 275 ident: bib21 article-title: Protein measurement with the Folin phenol reagent publication-title: J Biol Chem – volume: 285 start-page: 18473 year: 2010 end-page: 18484 ident: bib28 article-title: Modifying apolipoprotein A-I by malondialdehyde, but not by an array of other reactive carbonyls, blocks cholesterol efflux by the ABCA1 pathway publication-title: J Biol Chem – volume: 12 start-page: 444 year: 1974 end-page: 448 ident: bib23 article-title: An improved coupled test procedure for glutathione peroxidase in blood publication-title: Z Klin Chem Klin Biochem – volume: 72 start-page: A31 year: 2008 end-page: A37 ident: bib35 article-title: Oxidative stress and mitochondrial DNA damage in heart failure publication-title: Circ J – volume: 15 start-page: 770 year: 2009 end-page: 774 ident: bib12 article-title: Antibodies to oxidized LDL as predictors of morbidity and mortality in patients with chronic heart failure publication-title: J Card Fail – volume: 281 start-page: 1718 year: 1999 end-page: 1721 ident: bib27 article-title: Malondialdehyde-modified LDL as a marker of acute coronary syndromes publication-title: J Am Med Assoc – volume: 11 start-page: 444 year: 2009 end-page: 452 ident: bib6 article-title: Oxidative stress and hyperuricaemia: pathophysiology, clinical relevance, and therapeutic implications in chronic heart failure publication-title: Eur J Heart Fail – volume: 65 start-page: 245 year: 1991 end-page: 248 ident: bib17 article-title: Oxygen free radicals and congestive heart failure publication-title: Br Heart J – volume: 11 start-page: 13 year: 2006 end-page: 17 ident: bib32 article-title: Selenium and antioxidant defenses as major mediators in the development of chronic heart failure publication-title: Heart Fail Rev – volume: 89 start-page: 871 year: 2003 end-page: 874 ident: bib8 article-title: Increased urinary 15-F2t-isoprostane concentrations in patients with non-ischaemic congestive heart failure: a marker of oxidative stress publication-title: Heart – volume: 14 start-page: 2230 year: 2009 end-page: 2237 ident: bib24 article-title: Role of oxidative and nitrosative stress biomarkers in chronic heart failure publication-title: Front Biosci – volume: 13 start-page: 109 year: 2008 end-page: 116 ident: bib10 article-title: Markers of oxidative damage in chronic heart failure: Role in disease progression publication-title: Redox Rep – volume: 233 start-page: 346 year: 1994 end-page: 357 ident: bib19 article-title: Carbonyl assays for determination of oxidatively modified proteins publication-title: Methods Enzymol – volume: 115 start-page: 500 year: 2005 end-page: 508 ident: bib3 article-title: Oxygen, oxidative stress, hypoxia and heart failure publication-title: J Clin Invest – volume: 56 start-page: 1078 year: 1999 end-page: 1083 ident: bib25 article-title: Serum malondialdehyde and prevalent cardiovascular disease in hemodialysis publication-title: Kidney Int – volume: 555 start-page: 589 year: 2004 end-page: 606 ident: bib42 article-title: Xanthine oxidoreductase and cardiovascular disease: molecular mechanisms and pathophysiological implications publication-title: J Physiol – volume: 93 start-page: 903 year: 2007 end-page: 907 ident: bib1 article-title: Oxidative stress and redox signalling in cardiac hypertrophy and heart failure publication-title: Heart – volume: 3 start-page: 717 year: 2005 end-page: 732 ident: bib4 article-title: Prevention of remodeling in congestive heart failure due to myocardial infarction by blockade of the renin-angiotensin system publication-title: Expert Rev Cardiovasc Ther – volume: 62 start-page: 463 year: 2002 end-page: 468 ident: bib29 article-title: Evidence of increased oxidative stress by simple measurements in patients with dilated cardiomyopathy publication-title: Scand J Clin Lab Invest – volume: 143 start-page: 44 year: 1987 end-page: 67 ident: bib20 article-title: Spectrophotometric assay of thiols publication-title: Methods Enzymol – volume: 19 start-page: 537 year: 2005 end-page: 541 ident: bib5 article-title: Antioxidant status and biomarkers of oxidative stress in dogs with congestive heart failure publication-title: J Vet Intern Med – volume: 269 start-page: 2405 year: 1994 end-page: 2410 ident: bib30 article-title: Identification of oxidized histidine generated at the active site of Cu, Zn-superoxide dismutase exposed to H publication-title: J Biol Chem – volume: 247 start-page: 3170 year: 1972 end-page: 3175 ident: bib22 article-title: The role of superoxide anion in the autooxidation of epinephrine and a simple assay for superoxide dismutase publication-title: J Biol Chem – volume: 89 start-page: 871 year: 2003 ident: 10.1016/j.cardfail.2012.04.003_bib8 article-title: Increased urinary 15-F2t-isoprostane concentrations in patients with non-ischaemic congestive heart failure: a marker of oxidative stress publication-title: Heart doi: 10.1136/heart.89.8.871 – volume: 3 start-page: 717 year: 2005 ident: 10.1016/j.cardfail.2012.04.003_bib4 article-title: Prevention of remodeling in congestive heart failure due to myocardial infarction by blockade of the renin-angiotensin system publication-title: Expert Rev Cardiovasc Ther doi: 10.1586/14779072.3.4.717 – volume: 269 start-page: 2405 year: 1994 ident: 10.1016/j.cardfail.2012.04.003_bib30 article-title: Identification of oxidized histidine generated at the active site of Cu, Zn-superoxide dismutase exposed to H2O2. Selective generation of 2-oxo-histidine at the histidine 118 publication-title: J Biol Chem doi: 10.1016/S0021-9258(17)41960-0 – volume: 39 start-page: 957 year: 2002 ident: 10.1016/j.cardfail.2012.04.003_bib11 article-title: Plasma oxidized low-density lipoprotein as a prognostic predictor in patients with chronic congestive heart failure publication-title: J Am Coll Cardiol doi: 10.1016/S0735-1097(02)01721-7 – volume: 56 start-page: 1078 year: 1999 ident: 10.1016/j.cardfail.2012.04.003_bib25 article-title: Serum malondialdehyde and prevalent cardiovascular disease in hemodialysis publication-title: Kidney Int doi: 10.1046/j.1523-1755.1999.00613.x – volume: 193 start-page: 265 year: 1951 ident: 10.1016/j.cardfail.2012.04.003_bib21 article-title: Protein measurement with the Folin phenol reagent publication-title: J Biol Chem doi: 10.1016/S0021-9258(19)52451-6 – volume: 8 start-page: 1 year: 2001 ident: 10.1016/j.cardfail.2012.04.003_bib15 article-title: Oxidative modification of plasma proteins in different stages of chronic renal failure publication-title: Facta Universitatis – volume: 4 start-page: e4871 year: 2009 ident: 10.1016/j.cardfail.2012.04.003_bib33 article-title: Glutathione deficiency in cardiac patients is related to the functional status and structural cardiac abnormalities publication-title: PLoS One doi: 10.1371/journal.pone.0004871 – volume: 293 start-page: R284 year: 2007 ident: 10.1016/j.cardfail.2012.04.003_bib37 article-title: Development of contractile dysfunction in rat heart failure; hierarchy of cellular events publication-title: Am J Physiol Regul Integr Comp Physiol doi: 10.1152/ajpregu.00880.2006 – volume: 131 start-page: 146 year: 1996 ident: 10.1016/j.cardfail.2012.04.003_bib9 article-title: Increased malondialdehide in peripheral blood of patients with congestive heart failure publication-title: Am Heart J doi: 10.1016/S0002-8703(96)90063-0 – volume: 115 start-page: 500 year: 2005 ident: 10.1016/j.cardfail.2012.04.003_bib3 article-title: Oxygen, oxidative stress, hypoxia and heart failure publication-title: J Clin Invest doi: 10.1172/JCI200524408 – volume: 65 start-page: 245 year: 1991 ident: 10.1016/j.cardfail.2012.04.003_bib17 article-title: Oxygen free radicals and congestive heart failure publication-title: Br Heart J doi: 10.1136/hrt.65.5.245 – start-page: 268 year: 2007 ident: 10.1016/j.cardfail.2012.04.003_bib14 article-title: Measurement of reactive species – volume: 18 start-page: 737 year: 2003 ident: 10.1016/j.cardfail.2012.04.003_bib26 article-title: Cardiac troponin T and malondialdehyde modified plasma lipids in haemodialysis patients publication-title: Nephrol Dial Transplant doi: 10.1093/ndt/gfg020 – volume: 19 start-page: 537 year: 2005 ident: 10.1016/j.cardfail.2012.04.003_bib5 article-title: Antioxidant status and biomarkers of oxidative stress in dogs with congestive heart failure publication-title: J Vet Intern Med doi: 10.1111/j.1939-1676.2005.tb02724.x – volume: 72 start-page: A31 year: 2008 ident: 10.1016/j.cardfail.2012.04.003_bib35 article-title: Oxidative stress and mitochondrial DNA damage in heart failure publication-title: Circ J doi: 10.1253/circj.CJ-08-0014 – volume: 13 start-page: 109 year: 2008 ident: 10.1016/j.cardfail.2012.04.003_bib10 article-title: Markers of oxidative damage in chronic heart failure: Role in disease progression publication-title: Redox Rep doi: 10.1179/135100008X259204 – volume: 93 start-page: 903 year: 2007 ident: 10.1016/j.cardfail.2012.04.003_bib1 article-title: Oxidative stress and redox signalling in cardiac hypertrophy and heart failure publication-title: Heart doi: 10.1136/hrt.2005.068270 – volume: 37 start-page: 63 year: 2004 ident: 10.1016/j.cardfail.2012.04.003_bib7 article-title: Mitochondrial Ca2+ flux and respiratory enzyme activity decline are early events in cardiomyocyte response to H2O2 publication-title: J Mol Cell Cardiol doi: 10.1016/j.yjmcc.2004.04.001 – volume: 281 start-page: 1718 year: 1999 ident: 10.1016/j.cardfail.2012.04.003_bib27 article-title: Malondialdehyde-modified LDL as a marker of acute coronary syndromes publication-title: J Am Med Assoc doi: 10.1001/jama.281.18.1718 – volume: 247 start-page: 3170 year: 1972 ident: 10.1016/j.cardfail.2012.04.003_bib22 article-title: The role of superoxide anion in the autooxidation of epinephrine and a simple assay for superoxide dismutase publication-title: J Biol Chem doi: 10.1016/S0021-9258(19)45228-9 – volume: 35 start-page: 827 year: 2008 ident: 10.1016/j.cardfail.2012.04.003_bib38 article-title: Defective intracellular Ca2+ homeostasis contributes to myocyte dysfunction during ventricular remodeling induced by chronic volume overload in rats publication-title: Clin Exp Pharmacol Physiol doi: 10.1111/j.1440-1681.2008.04923.x – volume: 91 start-page: 406 year: 2002 ident: 10.1016/j.cardfail.2012.04.003_bib41 article-title: Angiotensin II stimulation of NAD(P)H oxidase activity: upstream mediators publication-title: Circ Res doi: 10.1161/01.RES.0000033523.08033.16 – volume: 72 start-page: 1512 year: 2008 ident: 10.1016/j.cardfail.2012.04.003_bib36 article-title: Beneficial effects of exogenous tetrahydrobiopterin on left ventricular remodeling after myocardial infarction in rats: the possible role of oxidative stress caused by uncoupled endothelial nitric oxide synthase publication-title: Circ J doi: 10.1253/circj.CJ-08-0072 – volume: 555 start-page: 589 year: 2004 ident: 10.1016/j.cardfail.2012.04.003_bib42 article-title: Xanthine oxidoreductase and cardiovascular disease: molecular mechanisms and pathophysiological implications publication-title: J Physiol doi: 10.1113/jphysiol.2003.055913 – volume: 285 start-page: 18473 year: 2010 ident: 10.1016/j.cardfail.2012.04.003_bib28 article-title: Modifying apolipoprotein A-I by malondialdehyde, but not by an array of other reactive carbonyls, blocks cholesterol efflux by the ABCA1 pathway publication-title: J Biol Chem doi: 10.1074/jbc.M110.118182 – volume: 2 start-page: 358 year: 1989 ident: 10.1016/j.cardfail.2012.04.003_bib18 article-title: Recommendations for quantitation of the left ventricle by two-dimensional echocardiography. American Society of Echocardiography Committee on Standards, Subcommittee on Quantitation of Two-Dimensional Echocardiograms publication-title: J Am Soc Echocardiogr doi: 10.1016/S0894-7317(89)80014-8 – volume: 14 start-page: 2230 year: 2009 ident: 10.1016/j.cardfail.2012.04.003_bib24 article-title: Role of oxidative and nitrosative stress biomarkers in chronic heart failure publication-title: Front Biosci doi: 10.2741/3375 – volume: 15 start-page: 770 year: 2009 ident: 10.1016/j.cardfail.2012.04.003_bib12 article-title: Antibodies to oxidized LDL as predictors of morbidity and mortality in patients with chronic heart failure publication-title: J Card Fail doi: 10.1016/j.cardfail.2009.05.009 – volume: 98 start-page: 2572 year: 1996 ident: 10.1016/j.cardfail.2012.04.003_bib40 article-title: Reactive oxygen species produced by macrophage-derived foam cells regulate the activity of vascular matrix metalloproteinases in vitro. Implications for atherosclerotic plaque stability publication-title: J Clin Invest doi: 10.1172/JCI119076 – volume: 143 start-page: 44 year: 1987 ident: 10.1016/j.cardfail.2012.04.003_bib20 article-title: Spectrophotometric assay of thiols publication-title: Methods Enzymol doi: 10.1016/0076-6879(87)43013-9 – volume: 62 start-page: 463 year: 2002 ident: 10.1016/j.cardfail.2012.04.003_bib29 article-title: Evidence of increased oxidative stress by simple measurements in patients with dilated cardiomyopathy publication-title: Scand J Clin Lab Invest doi: 10.1080/00365510260390019 – volume: 324 start-page: 1 year: 1997 ident: 10.1016/j.cardfail.2012.04.003_bib13 article-title: Biochemistry and pathology of radical-mediated protein oxidation publication-title: Biochem J doi: 10.1042/bj3240001 – volume: 12 start-page: 444 year: 1974 ident: 10.1016/j.cardfail.2012.04.003_bib23 article-title: An improved coupled test procedure for glutathione peroxidase in blood publication-title: Z Klin Chem Klin Biochem – volume: 11 start-page: 444 year: 2009 ident: 10.1016/j.cardfail.2012.04.003_bib6 article-title: Oxidative stress and hyperuricaemia: pathophysiology, clinical relevance, and therapeutic implications in chronic heart failure publication-title: Eur J Heart Fail doi: 10.1093/eurjhf/hfp042 – volume: 43 start-page: 2000 year: 2004 ident: 10.1016/j.cardfail.2012.04.003_bib2 article-title: Hydroxyl radical generation, levels of tumor necrosis factor-alpha, and progression to heart failure after acute myocardial infarction publication-title: J Am Coll Cardiol doi: 10.1016/j.jacc.2004.01.036 – volume: 106 start-page: 3073 year: 2002 ident: 10.1016/j.cardfail.2012.04.003_bib31 article-title: Vascular oxidative stress and endothelial dysfunction in patients with chronic heart failure: role of xanthine-oxidase and extracellular superoxide dismutase publication-title: Circulation doi: 10.1161/01.CIR.0000041431.57222.AF – volume: 11 start-page: 13 year: 2006 ident: 10.1016/j.cardfail.2012.04.003_bib32 article-title: Selenium and antioxidant defenses as major mediators in the development of chronic heart failure publication-title: Heart Fail Rev doi: 10.1007/s10741-006-9188-2 – volume: 22 start-page: 2176 year: 2008 ident: 10.1016/j.cardfail.2012.04.003_bib34 article-title: Dysregulation of adipose glutathione peroxidase 3 in obesity contributes to local and systemic oxidative stress publication-title: Mol Endocrinol doi: 10.1210/me.2008-0023 – volume: 3 start-page: 306 year: 2010 ident: 10.1016/j.cardfail.2012.04.003_bib39 article-title: Cardiac-specific overexpression of catalase identifies hydrogen peroxide-dependent and -independent phases of myocardial remodeling and prevents the progression to overt heart failure in G(alpha)q-overexpressing transgenic mice publication-title: Circ Heart Fail doi: 10.1161/CIRCHEARTFAILURE.109.864785 – volume: 20 start-page: 149 year: 2006 ident: 10.1016/j.cardfail.2012.04.003_bib16 article-title: Byproducts of oxidative protein damage and antioxidant enzyme activities in plasma of patients with different degrees of essential hypertension publication-title: J Hum Hypertens doi: 10.1038/sj.jhh.1001945 – volume: 233 start-page: 346 year: 1994 ident: 10.1016/j.cardfail.2012.04.003_bib19 article-title: Carbonyl assays for determination of oxidatively modified proteins publication-title: Methods Enzymol doi: 10.1016/S0076-6879(94)33040-9
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Snippet	Although the majority of previous findings unequivocally confirmed the existence of systemic oxidative stress in chronic heart failure (CHF) patients, data on... Abstract Background Although the majority of previous findings unequivocally confirmed the existence of systemic oxidative stress in chronic heart failure...
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SubjectTerms	Aged Biomarkers - blood Cardiovascular Case-Control Studies Chronic Disease Cohort Studies Disease Progression Echocardiography Female Follow-Up Studies glutathione peroxidase Glutathione Peroxidase - blood Heart Failure - blood Heart Failure - mortality Humans Lipid Peroxidation - physiology Male malondialdehyde Malondialdehyde - blood Middle Aged Oxidative stress Oxidative Stress - physiology Oxidoreductases - blood reactive carbonyl derivatives remodeling Superoxide Dismutase - blood Ventricular Remodeling - physiology
Title	Markers of Oxidative Damage and Antioxidant Enzyme Activities as Predictors of Morbidity and Mortality in Patients With Chronic Heart Failure
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