Markers of Oxidative Damage and Antioxidant Enzyme Activities as Predictors of Morbidity and Mortality in Patients With Chronic Heart Failure

Although the majority of previous findings unequivocally confirmed the existence of systemic oxidative stress in chronic heart failure (CHF) patients, data on prognostic potential of biomarkers of oxidative lipid and protein damage are limited. We aimed to address the relation of oxidative stress ma...

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Vydané v:Journal of cardiac failure Ročník 18; číslo 6; s. 493 - 501
Hlavní autori: Radovanovic, Slavica, Savic-Radojevic, Ana, Pljesa-Ercegovac, Marija, Djukic, Tatjana, Suvakov, Sonja, Krotin, Mirjana, Simic, Dragan V., Matic, Marija, Radojicic, Zoran, Pekmezovic, Tatjana, Simic, Tatjana
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: United States Elsevier Inc 01.06.2012
Predmet:
Aged
Biomarkers - blood
Cardiovascular
Case-Control Studies
Chronic Disease
Cohort Studies
Disease Progression
Echocardiography
Female
Follow-Up Studies
glutathione peroxidase
Glutathione Peroxidase - blood
Heart Failure - blood
Heart Failure - mortality
Humans
Lipid Peroxidation - physiology
Male
malondialdehyde
Malondialdehyde - blood
Middle Aged
Oxidative stress
Oxidative Stress - physiology
Oxidoreductases - blood
reactive carbonyl derivatives
remodeling
Superoxide Dismutase - blood
Ventricular Remodeling - physiology
Oxidative stress
remodeling
reactive carbonyl derivatives
malondialdehyde
glutathione peroxidase
ISSN:1071-9164, 1532-8414, 1532-8414
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Shrnutí:Although the majority of previous findings unequivocally confirmed the existence of systemic oxidative stress in chronic heart failure (CHF) patients, data on prognostic potential of biomarkers of oxidative lipid and protein damage are limited. We aimed to address the relation of oxidative stress markers to severity and prognosis in CHF secondary to ischemic cardiomyopathy. Plasma malondialdehyde (MDA), protein thiol groups (P-SH), reactive carbonyl derivatives (RCD), together with glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) activities were determined in 120 CHF patients and 69 healthy controls. Increased lipid peroxidation (MDA) and oxidation of plasma proteins (RCD; P-SH) s well as downregulated GSH-Px activity were found in CHF patients compared with controls. Significant correlation was obtained only for RCD content and remodeling indices (LVEDV: r = 0.469, P = .008; LVESV: r = 0.452; P = .011). Cox regression analysis demonstrated only MDA (HR = 3.33; CI: 1.55–7.12; P = .002) as independent predictor of death, whereas SOD was associated with unstable angina pectoris (HR = 2.09; CI: 1.16–3.78; P = .011). In the course of CHF progression, carbonyl stress is implicated in the LV remodeling. Malondialdehyde level might be a useful parameter for monitoring and planning management of CHF patients.
Bibliografia:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1071-9164
1532-8414
1532-8414
DOI:10.1016/j.cardfail.2012.04.003