Circulating Cell-Free mtDNA Contributes to AIM2 Inflammasome-Mediated Chronic Inflammation in Patients with Type 2 Diabetes

Mitochondrial dysfunction has been implicated in the pathogenesis of insulin resistance and type 2 diabetes. Damaged mitochondria DNA (mtDNA) may have a role in regulating hyperglycemia during type 2 diabetes. Circulating cell-free mitochondria DNA (ccf-mtDNA) was found in serum and plasma from pati...

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Veröffentlicht in:	Cells (Basel, Switzerland) Jg. 8; H. 4; S. 328
Hauptverfasser:	Bae, Jung Hwan, Jo, Seung, Kim, Seong Jin, Lee, Jong Min, Jeong, Ji Hun, Kang, Jeong Suk, Cho, Nam-Jun, Kim, Sang Soo, Lee, Eun Young, Moon, Jong-Seok
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Switzerland MDPI AG 08.04.2019 MDPI
Schlagworte:	Aged AIM2 inflammasome Alzheimer's disease Animals Bone marrow Cardiovascular disease Case-Control Studies Caspase-1 ccf-mtDNA Cells, Cultured Chronic illnesses chronic inflammation Cloning Cytokines Dehydrogenases Diabetes Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 - metabolism Diabetes Mellitus, Type 2 - pathology DNA, Mitochondrial - blood DNA-Binding Proteins - blood Enrollments Female Health care Human subjects Humans Hyperglycemia IL-1β Inflammasomes Inflammasomes - metabolism Inflammation Inflammation - metabolism Inflammation - pathology Insulin Insulin resistance Interleukin 18 Interleukin-18 - blood Interleukin-1beta - blood Kidney diseases Macrophages Macrophages - metabolism Macrophages - pathology Male Manufacturers Melanoma Middle Aged Mitochondrial DNA Plasma Proteins type 2 diabetes Minneapolis Minnesota United States > US type 2 diabetes AIM2 inflammasome chronic inflammation ccf-mtDNA
ISSN:	2073-4409, 2073-4409
Online-Zugang:	Volltext
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