Circulating Cell-Free mtDNA Contributes to AIM2 Inflammasome-Mediated Chronic Inflammation in Patients with Type 2 Diabetes

Mitochondrial dysfunction has been implicated in the pathogenesis of insulin resistance and type 2 diabetes. Damaged mitochondria DNA (mtDNA) may have a role in regulating hyperglycemia during type 2 diabetes. Circulating cell-free mitochondria DNA (ccf-mtDNA) was found in serum and plasma from pati...

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Bibliographic Details
Published in:Cells (Basel, Switzerland) Vol. 8; no. 4; p. 328
Main Authors: Bae, Jung Hwan, Jo, Seung, Kim, Seong Jin, Lee, Jong Min, Jeong, Ji Hun, Kang, Jeong Suk, Cho, Nam-Jun, Kim, Sang Soo, Lee, Eun Young, Moon, Jong-Seok
Format: Journal Article
Language:English
Published: Switzerland MDPI AG 08.04.2019
MDPI
Subjects:
Aged
AIM2 inflammasome
Alzheimer's disease
Animals
Bone marrow
Cardiovascular disease
Case-Control Studies
Caspase-1
ccf-mtDNA
Cells, Cultured
Chronic illnesses
chronic inflammation
Cloning
Cytokines
Dehydrogenases
Diabetes
Diabetes mellitus (non-insulin dependent)
Diabetes Mellitus, Type 2 - metabolism
Diabetes Mellitus, Type 2 - pathology
DNA, Mitochondrial - blood
DNA-Binding Proteins - blood
Enrollments
Female
Health care
Human subjects
Humans
Hyperglycemia
IL-1β
Inflammasomes
Inflammasomes - metabolism
Inflammation
Inflammation - metabolism
Inflammation - pathology
Insulin
Insulin resistance
Interleukin 18
Interleukin-18 - blood
Interleukin-1beta - blood
Kidney diseases
Macrophages
Macrophages - metabolism
Macrophages - pathology
Male
Manufacturers
Melanoma
Middle Aged
Mitochondrial DNA
Plasma
Proteins
type 2 diabetes
Minneapolis Minnesota
United States > US
type 2 diabetes
AIM2 inflammasome
chronic inflammation
ccf-mtDNA
ISSN:2073-4409, 2073-4409
Online Access:Get full text
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Summary:Mitochondrial dysfunction has been implicated in the pathogenesis of insulin resistance and type 2 diabetes. Damaged mitochondria DNA (mtDNA) may have a role in regulating hyperglycemia during type 2 diabetes. Circulating cell-free mitochondria DNA (ccf-mtDNA) was found in serum and plasma from patients and has been linked to the prognosis factors in various human diseases. However, the role of ccf-mtDNA in chronic inflammation in type 2 diabetes is unclear. In this study, we hypothesized that the ccf-mtDNA levels are associated with chronic inflammation in patients with type 2 diabetes. The mtDNA levels were elevated in the plasma from patients with type 2 diabetes compared to healthy subjects. The elevated mtDNA levels were associated with interleukin-1β (IL-1β) levels in patients with type 2 diabetes. The mtDNA, from patients with type 2 diabetes, induced absent in melanoma 2 (AIM2) inflammasome-dependent caspase-1 activation and IL-1β and IL-18 secretion in macrophages. Our results suggest that the ccf-mtDNA might contribute to AIM2 inflammasome-mediated chronic inflammation in type 2 diabetes.
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ISSN:2073-4409
2073-4409
DOI:10.3390/cells8040328