Circulating Cell-Free mtDNA Contributes to AIM2 Inflammasome-Mediated Chronic Inflammation in Patients with Type 2 Diabetes

Mitochondrial dysfunction has been implicated in the pathogenesis of insulin resistance and type 2 diabetes. Damaged mitochondria DNA (mtDNA) may have a role in regulating hyperglycemia during type 2 diabetes. Circulating cell-free mitochondria DNA (ccf-mtDNA) was found in serum and plasma from pati...

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Vydáno v:Cells (Basel, Switzerland) Ročník 8; číslo 4; s. 328
Hlavní autoři: Bae, Jung Hwan, Jo, Seung, Kim, Seong Jin, Lee, Jong Min, Jeong, Ji Hun, Kang, Jeong Suk, Cho, Nam-Jun, Kim, Sang Soo, Lee, Eun Young, Moon, Jong-Seok
Médium: Journal Article
Jazyk:angličtina
Vydáno: Switzerland MDPI AG 08.04.2019
MDPI
Témata:
Aged
AIM2 inflammasome
Alzheimer's disease
Animals
Bone marrow
Cardiovascular disease
Case-Control Studies
Caspase-1
ccf-mtDNA
Cells, Cultured
Chronic illnesses
chronic inflammation
Cloning
Cytokines
Dehydrogenases
Diabetes
Diabetes mellitus (non-insulin dependent)
Diabetes Mellitus, Type 2 - metabolism
Diabetes Mellitus, Type 2 - pathology
DNA, Mitochondrial - blood
DNA-Binding Proteins - blood
Enrollments
Female
Health care
Human subjects
Humans
Hyperglycemia
IL-1β
Inflammasomes
Inflammasomes - metabolism
Inflammation
Inflammation - metabolism
Inflammation - pathology
Insulin
Insulin resistance
Interleukin 18
Interleukin-18 - blood
Interleukin-1beta - blood
Kidney diseases
Macrophages
Macrophages - metabolism
Macrophages - pathology
Male
Manufacturers
Melanoma
Middle Aged
Mitochondrial DNA
Plasma
Proteins
type 2 diabetes
Minneapolis Minnesota
United States > US
type 2 diabetes
AIM2 inflammasome
chronic inflammation
ccf-mtDNA
ISSN:2073-4409, 2073-4409
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Abstract Mitochondrial dysfunction has been implicated in the pathogenesis of insulin resistance and type 2 diabetes. Damaged mitochondria DNA (mtDNA) may have a role in regulating hyperglycemia during type 2 diabetes. Circulating cell-free mitochondria DNA (ccf-mtDNA) was found in serum and plasma from patients and has been linked to the prognosis factors in various human diseases. However, the role of ccf-mtDNA in chronic inflammation in type 2 diabetes is unclear. In this study, we hypothesized that the ccf-mtDNA levels are associated with chronic inflammation in patients with type 2 diabetes. The mtDNA levels were elevated in the plasma from patients with type 2 diabetes compared to healthy subjects. The elevated mtDNA levels were associated with interleukin-1β (IL-1β) levels in patients with type 2 diabetes. The mtDNA, from patients with type 2 diabetes, induced absent in melanoma 2 (AIM2) inflammasome-dependent caspase-1 activation and IL-1β and IL-18 secretion in macrophages. Our results suggest that the ccf-mtDNA might contribute to AIM2 inflammasome-mediated chronic inflammation in type 2 diabetes.
AbstractList Mitochondrial dysfunction has been implicated in the pathogenesis of insulin resistance and type 2 diabetes. Damaged mitochondria DNA (mtDNA) may have a role in regulating hyperglycemia during type 2 diabetes. Circulating cell-free mitochondria DNA (ccf-mtDNA) was found in serum and plasma from patients and has been linked to the prognosis factors in various human diseases. However, the role of ccf-mtDNA in chronic inflammation in type 2 diabetes is unclear. In this study, we hypothesized that the ccf-mtDNA levels are associated with chronic inflammation in patients with type 2 diabetes. The mtDNA levels were elevated in the plasma from patients with type 2 diabetes compared to healthy subjects. The elevated mtDNA levels were associated with interleukin-1β (IL-1β) levels in patients with type 2 diabetes. The mtDNA, from patients with type 2 diabetes, induced absent in melanoma 2 (AIM2) inflammasome-dependent caspase-1 activation and IL-1β and IL-18 secretion in macrophages. Our results suggest that the ccf-mtDNA might contribute to AIM2 inflammasome-mediated chronic inflammation in type 2 diabetes.
Mitochondrial dysfunction has been implicated in the pathogenesis of insulin resistance and type 2 diabetes. Damaged mitochondria DNA (mtDNA) may have a role in regulating hyperglycemia during type 2 diabetes. Circulating cell-free mitochondria DNA (ccf-mtDNA) was found in serum and plasma from patients and has been linked to the prognosis factors in various human diseases. However, the role of ccf-mtDNA in chronic inflammation in type 2 diabetes is unclear. In this study, we hypothesized that the ccf-mtDNA levels are associated with chronic inflammation in patients with type 2 diabetes. The mtDNA levels were elevated in the plasma from patients with type 2 diabetes compared to healthy subjects. The elevated mtDNA levels were associated with interleukin-1 (IL-1)β levels in patients with type 2 diabetes. The mtDNA, from patients with type 2 diabetes, induced absent in melanoma 2 (AIM2) inflammasome-dependent caspase-1 activation and IL-1β and IL-18 secretion in macrophages. Our results suggest that the ccf-mtDNA might contribute to AIM2 inflammasome-mediated chronic inflammation in type 2 diabetes.Mitochondrial dysfunction has been implicated in the pathogenesis of insulin resistance and type 2 diabetes. Damaged mitochondria DNA (mtDNA) may have a role in regulating hyperglycemia during type 2 diabetes. Circulating cell-free mitochondria DNA (ccf-mtDNA) was found in serum and plasma from patients and has been linked to the prognosis factors in various human diseases. However, the role of ccf-mtDNA in chronic inflammation in type 2 diabetes is unclear. In this study, we hypothesized that the ccf-mtDNA levels are associated with chronic inflammation in patients with type 2 diabetes. The mtDNA levels were elevated in the plasma from patients with type 2 diabetes compared to healthy subjects. The elevated mtDNA levels were associated with interleukin-1 (IL-1)β levels in patients with type 2 diabetes. The mtDNA, from patients with type 2 diabetes, induced absent in melanoma 2 (AIM2) inflammasome-dependent caspase-1 activation and IL-1β and IL-18 secretion in macrophages. Our results suggest that the ccf-mtDNA might contribute to AIM2 inflammasome-mediated chronic inflammation in type 2 diabetes.
Mitochondrial dysfunction has been implicated in the pathogenesis of insulin resistance and type 2 diabetes. Damaged mitochondria DNA (mtDNA) may have a role in regulating hyperglycemia during type 2 diabetes. Circulating cell-free mitochondria DNA (ccf-mtDNA) was found in serum and plasma from patients and has been linked to the prognosis factors in various human diseases. However, the role of ccf-mtDNA in chronic inflammation in type 2 diabetes is unclear. In this study, we hypothesized that the ccf-mtDNA levels are associated with chronic inflammation in patients with type 2 diabetes. The mtDNA levels were elevated in the plasma from patients with type 2 diabetes compared to healthy subjects. The elevated mtDNA levels were associated with interleukin-1 (IL-1)β levels in patients with type 2 diabetes. The mtDNA, from patients with type 2 diabetes, induced absent in melanoma 2 (AIM2) inflammasome-dependent caspase-1 activation and IL-1β and IL-18 secretion in macrophages. Our results suggest that the ccf-mtDNA might contribute to AIM2 inflammasome-mediated chronic inflammation in type 2 diabetes.
Author Bae, Jung Hwan
Kim, Seong Jin
Kang, Jeong Suk
Kim, Sang Soo
Jo, Seung
Cho, Nam-Jun
Lee, Eun Young
Lee, Jong Min
Jeong, Ji Hun
Moon, Jong-Seok
AuthorAffiliation 3 Institute of Tissue Regeneration, College of Medicine, Soonchunhyang University, Cheonan 31151, Korea
4 Department of Internal Medicine, Pusan National University Hospital, Pusan 50612, Korea; drsskim7@gmail.com
1 Department of Integrated Biomedical Science, Soonchunhyang Institute of Medi-bio Science (SIMS), Soonchunhyang University, Cheonan-si, Chungcheongnam-do 31151, Korea; junier24@naver.com (J.H.B.); 309cho@naver.com (S.J.II); tjdwls515@naver.com (S.J.K.); whdals7034@naver.com (J.M.L.); jihun@sch.ac.kr (J.H.J.)
2 Department of Internal Medicine, Soonchunhyang University Cheonan Hospital, Cheonan 31151, Korea; abalonea@naver.com (J.S.K.); c100086@schmc.ac.kr (N.-J.C.)
AuthorAffiliation_xml – name: 2 Department of Internal Medicine, Soonchunhyang University Cheonan Hospital, Cheonan 31151, Korea; abalonea@naver.com (J.S.K.); c100086@schmc.ac.kr (N.-J.C.)
– name: 4 Department of Internal Medicine, Pusan National University Hospital, Pusan 50612, Korea; drsskim7@gmail.com
– name: 3 Institute of Tissue Regeneration, College of Medicine, Soonchunhyang University, Cheonan 31151, Korea
– name: 1 Department of Integrated Biomedical Science, Soonchunhyang Institute of Medi-bio Science (SIMS), Soonchunhyang University, Cheonan-si, Chungcheongnam-do 31151, Korea; junier24@naver.com (J.H.B.); 309cho@naver.com (S.J.II); tjdwls515@naver.com (S.J.K.); whdals7034@naver.com (J.M.L.); jihun@sch.ac.kr (J.H.J.)
Author_xml – sequence: 1
  givenname: Jung Hwan
  surname: Bae
  fullname: Bae, Jung Hwan
– sequence: 2
  givenname: Seung
  surname: Jo
  fullname: Jo, Seung
– sequence: 3
  givenname: Seong Jin
  surname: Kim
  fullname: Kim, Seong Jin
– sequence: 4
  givenname: Jong Min
  surname: Lee
  fullname: Lee, Jong Min
– sequence: 5
  givenname: Ji Hun
  surname: Jeong
  fullname: Jeong, Ji Hun
– sequence: 6
  givenname: Jeong Suk
  surname: Kang
  fullname: Kang, Jeong Suk
– sequence: 7
  givenname: Nam-Jun
  surname: Cho
  fullname: Cho, Nam-Jun
– sequence: 8
  givenname: Sang Soo
  orcidid: 0000-0002-9687-8357
  surname: Kim
  fullname: Kim, Sang Soo
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– sequence: 10
  givenname: Jong-Seok
  orcidid: 0000-0002-2537-7854
  surname: Moon
  fullname: Moon, Jong-Seok
BackLink https://www.ncbi.nlm.nih.gov/pubmed/30965677$$D View this record in MEDLINE/PubMed
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ContentType Journal Article
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2019 by the authors. 2019
Copyright_xml – notice: 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
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Issue 4
Keywords type 2 diabetes
AIM2 inflammasome
chronic inflammation
ccf-mtDNA
Language English
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Snippet Mitochondrial dysfunction has been implicated in the pathogenesis of insulin resistance and type 2 diabetes. Damaged mitochondria DNA (mtDNA) may have a role...
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StartPage 328
SubjectTerms Aged
AIM2 inflammasome
Alzheimer's disease
Animals
Bone marrow
Cardiovascular disease
Case-Control Studies
Caspase-1
ccf-mtDNA
Cells, Cultured
Chronic illnesses
chronic inflammation
Cloning
Cytokines
Dehydrogenases
Diabetes
Diabetes mellitus (non-insulin dependent)
Diabetes Mellitus, Type 2 - metabolism
Diabetes Mellitus, Type 2 - pathology
DNA, Mitochondrial - blood
DNA-Binding Proteins - blood
Enrollments
Female
Health care
Human subjects
Humans
Hyperglycemia
IL-1β
Inflammasomes
Inflammasomes - metabolism
Inflammation
Inflammation - metabolism
Inflammation - pathology
Insulin
Insulin resistance
Interleukin 18
Interleukin-18 - blood
Interleukin-1beta - blood
Kidney diseases
Macrophages
Macrophages - metabolism
Macrophages - pathology
Male
Manufacturers
Melanoma
Middle Aged
Mitochondrial DNA
Plasma
Proteins
type 2 diabetes
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Title Circulating Cell-Free mtDNA Contributes to AIM2 Inflammasome-Mediated Chronic Inflammation in Patients with Type 2 Diabetes
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