An Asian-specific MPL genetic variant alters JAK-STAT signaling and influences platelet count in the population

Genomic discovery efforts for hematological traits have been successfully conducted through genome-wide association study on samples of predominantly European ancestry. We sought to conduct unbiased genetic discovery for coding variants that influence hematological traits in a Han Chinese population...

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Vydané v:	Human molecular genetics Ročník 30; číslo 9; s. 836
Hlavní autori:	Sun, Pengfei, Zhou, Wei, Fu, Yi, Cheung, Chloe Y Y, Dong, Yujun, Yang, Min-Lee, Zhang, He, Jia, Jia, Huo, Yong, Willer, Cristen J, Chen, Y Eugene, Tang, Clara S, Tse, Hung-Fat, Lam, Karen S L, Gao, Wei, Xu, Ming, Yu, Haiyi, Sham, Pak Chung, Zhang, Yan, Ganesh, Santhi K
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	England 28.05.2021
Predmet:	Asians - genetics Genome-Wide Association Study Humans Platelet Count Polymorphism, Single Nucleotide - genetics Receptors, Thrombopoietin - genetics Signal Transduction - genetics
ISSN:	1460-2083, 1460-2083
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