Replication catastrophe induced by cyclic hypoxia leads to increased APOBEC3B activity

Abstract Tumor heterogeneity includes variable and fluctuating oxygen concentrations, which result in the accumulation of hypoxic regions in most solid tumors. Tumor hypoxia leads to increased therapy resistance and has been linked to genomic instability. Here, we tested the hypothesis that exposure...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Nucleic acids research Jg. 49; H. 13; S. 7492 - 7506
Hauptverfasser:	Bader, Samuel B, Ma, Tiffany S, Simpson, Charlotte J, Liang, Jiachen, Maezono, Sakura Eri B, Olcina, Monica M, Buffa, Francesca M, Hammond, Ester M
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England Oxford University Press 21.07.2021
Schlagworte:	APOBEC Deaminases - metabolism Cell Hypoxia Cell Line, Tumor Cytidine Deaminase - metabolism Deamination DNA Replication Genome Integrity, Repair and Humans Hydroxyurea - toxicity Minor Histocompatibility Antigens - metabolism Neoplasms - enzymology Stress, Physiological - genetics
ISSN:	0305-1048, 1362-4962, 1362-4962
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!