Replication catastrophe induced by cyclic hypoxia leads to increased APOBEC3B activity

Abstract Tumor heterogeneity includes variable and fluctuating oxygen concentrations, which result in the accumulation of hypoxic regions in most solid tumors. Tumor hypoxia leads to increased therapy resistance and has been linked to genomic instability. Here, we tested the hypothesis that exposure...

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Bibliographic Details

Published in:	Nucleic acids research Vol. 49; no. 13; pp. 7492 - 7506
Main Authors:	Bader, Samuel B, Ma, Tiffany S, Simpson, Charlotte J, Liang, Jiachen, Maezono, Sakura Eri B, Olcina, Monica M, Buffa, Francesca M, Hammond, Ester M
Format:	Journal Article
Language:	English
Published:	England Oxford University Press 21.07.2021
Subjects:	APOBEC Deaminases - metabolism Cell Hypoxia Cell Line, Tumor Cytidine Deaminase - metabolism Deamination DNA Replication Genome Integrity, Repair and Humans Hydroxyurea - toxicity Minor Histocompatibility Antigens - metabolism Neoplasms - enzymology Stress, Physiological - genetics
ISSN:	0305-1048, 1362-4962, 1362-4962
Online Access:	Get full text
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