Fertility potential in a cohort of 65 men with previously acquired undescended testes

To evaluate testicular function in men with previously acquired undescended testes (AUDT) in whom spontaneous descent was awaited until puberty followed by orchiopexy in case of nondescent. Andrological evaluation including paternity, scrotal ultrasound, reproductive hormones, and semen analysis was...

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Bibliographic Details
Published in:Journal of pediatric surgery Vol. 49; no. 4; pp. 599 - 605
Main Authors: van Brakel, Jocelyn, Kranse, Ries, de Muinck Keizer-Schrama, Sabine M.P.F., Hendriks, A. Emile J., de Jong, Frank H., Hack, Wilfried W.M., van der Voort-Doedens, Laszla M., Bangma, Chris H., Hazebroek, Frans W., Dohle, Gert R.
Format: Journal Article
Language:English
Published: United States Elsevier Inc 01.04.2014
Subjects:
Acquired cryptorchidism
Adolescent
Adult
Case-Control Studies
Congenital cryptorchidism
Cryptorchidism - etiology
Cryptorchidism - physiopathology
Cryptorchidism - surgery
Fertility
Humans
Infertility, Male - etiology
Kaplan-Meier Estimate
Logistic Models
Male
Middle Aged
Orchiopexy
Pediatrics
Sperm Count
Sperm Motility
Surgery
Undescended testis
Young Adult
ART
OR
UDT
CI
Acquired cryptorchidism
Undescended testis
TTP
Fertility
Congenital cryptorchidism
Orchiopexy
AUDT
FSH
LH
CUDT
BMI
odds ratio
undescended testes
follicle-stimulating hormone
body mass index
luteinizing hormone
previously acquired undescended testes
time to first pregnancy
assisted reproductive treatment
confidence interval
previously congenital undescended testes
ISSN:0022-3468, 1531-5037, 1531-5037
Online Access:Get full text
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Summary:To evaluate testicular function in men with previously acquired undescended testes (AUDT) in whom spontaneous descent was awaited until puberty followed by orchiopexy in case of nondescent. Andrological evaluation including paternity, scrotal ultrasound, reproductive hormones, and semen analysis was performed in three groups: men with AUDT, healthy controls, and men with previously congenital undescended testes (CUDT). In comparison with controls, men with AUDT more often had significantly abnormal testicular consistency, smaller testes, lower sperm concentration, and less motile sperm. Except for more often a normal testicular consistency in men with AUDT, no differences were found between men with AUDT and men with CUDT. Also, no differences were found between men with AUDT which had spontaneously descended and men who underwent orchiopexy. Fertility potential in men with AUDT is compromised in comparison with healthy controls, but comparable with men with CUDT. This suggests that congenital and acquired UDT share the same etiology. No significant difference was found between men who had spontaneous descent and men needing orchiopexy. However, fertility potential is unknown for men after immediate surgery at diagnosis, and this should be a subject for future studies.
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ISSN:0022-3468
1531-5037
1531-5037
DOI:10.1016/j.jpedsurg.2013.09.020