Persistent plasticizers and bisphenol in the cheese of Tunisian markets induced biochemical and histopathological alterations in male BALB/c mice

Clinical evidences, experimental models, and epidemiology of many studies suggest that phthalate-based plasticizers , aliphatic ester , and bisphenol A (BPA) have major risks for humans by targeting different organs and body systems. The current study has been designed firstly to analyze three categ...

Celý popis

Uloženo v:

Podrobná bibliografie
Vydáno v:	Environmental science and pollution research international Ročník 25; číslo 7; s. 6545 - 6557
Hlavní autoři:	Beltifa, Asma, Feriani, Anouar, Macherki, Monia, Ghorbel, Asma, Ghazouani, Lakhdar, Di Bella, Giuseppa, Sire, Olivier, Van Loco, Joris, Reyns, Tim, Mansour, Hedi Ben
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Berlin/Heidelberg Springer Berlin Heidelberg 01.03.2018 Springer Nature B.V Springer Verlag
Témata:	Alanine Alanine transaminase Aliphatic compounds Animal models Aquatic Pollution Aspartate aminotransferase aspartate transaminase Atmospheric Protection/Air Quality Control/Air Pollution Biocompatibility Bis(2-ethylhexyl) phthalate Bisphenol A blood Butyl phthalate Cheese cheeses Chemical Sciences Creatinine Cyclohexane Dairy products Dibutyl phthalate Diisodecyl phthalate Diisononyl phthalate Earth and Environmental Science Ecotoxicology Environment Environmental Chemistry Environmental Health Environmental science Epidemiology hepatotoxicity histopathology humans Kidneys L-Lactate dehydrogenase Lactate dehydrogenase Lactic acid Liver males markets Material chemistry Mice nephrotoxicity Organs Phthalates Plasticizers Plastics Research Article risk Rodents Toxicity Urea urea nitrogen Uric acid Waste Water Technology Water Management Water Pollution Control Bisphenol A Plasticizers Environmental contamination Cheese Food contamination Acute toxicity
ISSN:	0944-1344, 1614-7499, 1614-7499
On-line přístup:	Získat plný text
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!

Popis
Shrnutí:	Clinical evidences, experimental models, and epidemiology of many studies suggest that phthalate-based plasticizers , aliphatic ester , and bisphenol A (BPA) have major risks for humans by targeting different organs and body systems. The current study has been designed firstly to analyze three categories of cheese with and without their exposure to the sun and packed in packages with an inner surface plastic-covered film in order to identify the dibutyl phthalate (DBP); benzyl butyl phthalate (BBP); bis(2-ethylhexyl) phthalate (DEHP); diisodecyl phthalate (DiDP); diisononyl phthalate (DiNP); and 1,2-cyclohexane dicarboxylic acid diisononyl ester (DINCH) by GC-MS/MS, except for the bisphenol A, which is by UPLC-MS/MS, and secondly to assess the toxicity of the identified chemical molecules and cheese samples on the liver and kidney of mice. Our results showed that the cheese contains high quantities of DBP and DEHP with the concentrations up to 0.46 and 2.339 mg/kg, respectively. Other types of cheese, such as rolled and triangular cheeses, contain little quantities of the all substances at concentrations below the standard limits. In vivo, the obtained data clearly demonstrated that the acute administration of DBP, DEHP, and the tested cheese significantly induced liver and kidney injuries in mice manifested by a rise in plasma alanine aminotransferase, aspartate aminotransferase, blood urea nitrogen, lactate dehydrogenase, urea, creatinine, and uric acid when compared with control animals. In addition, the histopathological study confirmed the perturbation of biochemical parameters and showed that the hepatic and renal structures were altered. Indeed, the hepatotoxic and nephrotoxic effects are more pronounced when cheese was exposed to the sun.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23
ISSN:	0944-1344 1614-7499 1614-7499
DOI:	10.1007/s11356-017-0857-6