Effect of the P-Selectin Inhibitor Crizanlizumab on Survival Free of Organ Support in Patients Hospitalized for COVID-19: A Randomized Controlled Trial

COVID-19 has been associated with endothelial injury, resultant microvascular inflammation and thrombosis. Activated endothelial cells release and express P-selectin and von Willebrand factor, both of which are elevated in severe COVID-19 and may be implicated in the disease pathophysiology. We hypo...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Circulation (New York, N.Y.) Jg. 148; H. 5; S. 381
Hauptverfasser:	Solomon, Scott D, Lowenstein, Charles J, Bhatt, Ankeet S, Peikert, Alexander, Vardeny, Orly, Kosiborod, Mikhail N, Berger, Jeffrey S, Reynolds, Harmony R, Mavromichalis, Stephanie, Barytol, Anya, Althouse, Andrew D, Luther, James F, Leifer, Eric S, Kindzelski, Andrei L, Cushman, Mary, Gong, Michelle N, Kornblith, Lucy Z, Khatri, Pooja, Kim, Keri S, Baumann Kreuziger, Lisa, Wahid, Lana, Kirwan, Bridget-Anne, Geraci, Mark W, Neal, Matthew D, Hochman, Judith S
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.08.2023
Schlagworte:	COVID-19 Endothelial Cells Humans P-Selectin SARS-CoV-2 Treatment Outcome COVID-19 crizanlizumab P-selectin
ISSN:	1524-4539, 1524-4539
Online-Zugang:	Weitere Angaben
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!