Effect of the P-Selectin Inhibitor Crizanlizumab on Survival Free of Organ Support in Patients Hospitalized for COVID-19: A Randomized Controlled Trial

COVID-19 has been associated with endothelial injury, resultant microvascular inflammation and thrombosis. Activated endothelial cells release and express P-selectin and von Willebrand factor, both of which are elevated in severe COVID-19 and may be implicated in the disease pathophysiology. We hypo...

Full description

Bibliographic Details

Published in:	Circulation (New York, N.Y.) Vol. 148; no. 5; p. 381
Main Authors:	Solomon, Scott D, Lowenstein, Charles J, Bhatt, Ankeet S, Peikert, Alexander, Vardeny, Orly, Kosiborod, Mikhail N, Berger, Jeffrey S, Reynolds, Harmony R, Mavromichalis, Stephanie, Barytol, Anya, Althouse, Andrew D, Luther, James F, Leifer, Eric S, Kindzelski, Andrei L, Cushman, Mary, Gong, Michelle N, Kornblith, Lucy Z, Khatri, Pooja, Kim, Keri S, Baumann Kreuziger, Lisa, Wahid, Lana, Kirwan, Bridget-Anne, Geraci, Mark W, Neal, Matthew D, Hochman, Judith S
Format:	Journal Article
Language:	English
Published:	United States 01.08.2023
Subjects:	COVID-19 Endothelial Cells Humans P-Selectin SARS-CoV-2 Treatment Outcome COVID-19 crizanlizumab P-selectin
ISSN:	1524-4539, 1524-4539
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!