The role of neutrophils in neuro-immune modulation

[Display omitted] •Neutrophils are an immunological and diffuse source of neurotransmitters.•Neutrophils regulate sensory neuron functions and vice-versa.•Neutrophils play a crucial role in inflammatory disorders in the central nervous system. Neutrophils are peripheral immune cells that represent t...

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Published in:Pharmacological research Vol. 151; p. 104580
Main Authors: Kanashiro, Alexandre, Hiroki, Carlos Hiroji, da Fonseca, Denise Morais, Birbrair, Alexander, Ferreira, Raphael Gomes, Bassi, Gabriel Shimizu, Fonseca, Mirian D., Kusuda, Ricardo, Cebinelli, Guilherme Cesar Martelossi, da Silva, Katiussia Pinho, Wanderley, Carlos Wagner, Menezes, Gustavo Batista, Alves-Fiho, José Carlos, Oliveira, André Gustavo, Cunha, Thiago M., Pupo, André Sampaio, Ulloa, Luis, Cunha, Fernando Queiroz
Format: Journal Article
Language:English
Published: Netherlands Elsevier Ltd 01.01.2020
Subjects:
Adrenoceptors
Animals
Humans
Immunity, Innate
Inflammation - immunology
Neuroimmunology
Neuroimmunomodulation
Neuroinflammation
Neurotransmitter Agents - immunology
Neutrophil
Neutrophils - immunology
Nicotinic receptors
Nociception
Pain - immunology
Sensory Receptor Cells - immunology
VMAT
BBB
ACh
ICAM-1
H2O2
Nicotinic receptors
InsP7
MPO
NF-κB
RNS
iNOS
LTB4
PAMPs
IL
MS
mAChRs
NETs
Adrenoceptors
ROS
CGRP
MET
NK
CFA
ELISA
NO
fMLP
GRP
H
CNS
C5a
DAMPs
IFN
IκB
nAChRs
DHPG
Neuroimmunology
SP
HPLC
βARs
CGD
PGE2
ARs
PMA
Neuroinflammation
VLA-4
HOCl
α7nAChR
TH
TNF-α
DRG
Neutrophil
VIP
Neuroimmunomodulation
HMGB-1
ISSN:1043-6618, 1096-1186, 1096-1186
Online Access:Get full text
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Summary:[Display omitted] •Neutrophils are an immunological and diffuse source of neurotransmitters.•Neutrophils regulate sensory neuron functions and vice-versa.•Neutrophils play a crucial role in inflammatory disorders in the central nervous system. Neutrophils are peripheral immune cells that represent the first recruited innate immune defense against infections and tissue injury. However, these cells can also induce overzealous responses and cause tissue damage. Although the role of neutrophils activating the immune system is well established, only recently their critical implications in neuro-immune interactions are becoming more relevant. Here, we review several aspects of neutrophils in the bidirectional regulation between the nervous and immune systems. First, the role of neutrophils as a diffuse source of acetylcholine and catecholamines is controversial as well as the effects of these neurotransmitters in neutrophil’s functions. Second, neutrophils contribute for the activation and sensitization of sensory neurons, and thereby, in events of nociception and pain. In addition, nociceptor activation promotes an axon reflex triggering a local release of neural mediators and provoking neutrophil activation. Third, the recruitment of neutrophils in inflammatory responses in the nervous system suggests these immune cells as innovative targets in the treatment of central infectious, neurological and neurodegenerative disorders. Multidisciplinary studies involving immunologists and neuroscientists are required to define the role of the neurons-neutrophils communication in the pathophysiology of infectious, inflammatory, and neurological disorders.
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ISSN:1043-6618
1096-1186
1096-1186
DOI:10.1016/j.phrs.2019.104580