Prednisolone dose-dependently influences inflammation and coagulation during human endotoxemia

The effects of steroids on the outcome of sepsis are dose dependent. Low doses appear to be beneficial, but high doses do not improve outcome for reasons that are insufficiently understood. The effects of steroids on systemic inflammation as a function of dose have not previously been studied in hum...

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Bibliographic Details
Published in:	Journal of Immunology Vol. 178; no. 3; pp. 1845 - 1851
Main Authors:	de Kruif, Martijn D, Lemaire, Lucienne C, Giebelen, Ida A, van Zoelen, Marieke A D, Pater, Jennie M, van den Pangaart, Petra S, Groot, Angelique P, de Vos, Alex F, Elliott, Peter J, Meijers, Joost C M, Levi, Marcel, van der Poll, Tom
Format:	Journal Article
Language:	English
Published:	United States 01.02.2007
Subjects:	Adult Biomarkers - blood Blood Coagulation - drug effects Chemokines - blood Cytokines - blood Cytokines - drug effects Dose-Response Relationship, Drug Endothelial Cells - drug effects Endotoxemia - drug therapy Endotoxemia - pathology Escherichia coli Fibrinolysis - drug effects Humans Inflammation - drug therapy Lipopolysaccharides - administration & dosage Male Neutrophil Activation - drug effects Prednisolone - administration & dosage Prednisolone - pharmacology
ISSN:	0022-1767, 1365-2567
Online Access:	Get full text
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