Metabolomics assessment reveals oxidative stress and altered energy production in the heart after ischemic acute kidney injury in mice

Acute kidney injury (AKI) is a systemic disease associated with widespread effects on distant organs, including the heart. Normal cardiac function is dependent on constant ATP generation, and the preferred method of energy production is via oxidative phosphorylation. Following direct ischemic cardia...

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Vydáno v:	Kidney international Ročník 95; číslo 3; s. 590
Hlavní autoři:	Fox, Benjamin M, Gil, Hyo-Wook, Kirkbride-Romeo, Lara, Bagchi, Rushita A, Wennersten, Sara A, Haefner, Korey R, Skrypnyk, Nataliya I, Brown, Carolyn N, Soranno, Danielle E, Gist, Katja M, Griffin, Benjamin R, Jovanovich, Anna, Reisz, Julie A, Wither, Matthew J, D'Alessandro, Angelo, Edelstein, Charles L, Clendenen, Nathan, McKinsey, Timothy A, Altmann, Christopher, Faubel, Sarah
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 01.03.2019
Témata:	Acute Kidney Injury - complications Acute Kidney Injury - etiology Acute Kidney Injury - metabolism Animals Cardio-Renal Syndrome - diagnosis Cardio-Renal Syndrome - etiology Cardio-Renal Syndrome - metabolism Disease Models, Animal Echocardiography Energy Metabolism Heart - diagnostic imaging Heart Failure, Diastolic - diagnosis Heart Failure, Diastolic - etiology Heart Failure, Diastolic - metabolism Humans Ischemia - complications Ischemia - etiology Ischemia - metabolism Kidney - blood supply Kidney - pathology Male Metabolome Metabolomics Mice Myocardium - metabolism Myocardium - pathology Oxidative Stress acute kidney injury organ crosstalk metabolomics cardiorenal syndrome
ISSN:	1523-1755, 1523-1755
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