Liposome-Based Drug Delivery Systems in Cancer Immunotherapy

Cancer immunotherapy has shown remarkable progress in recent years. Nanocarriers, such as liposomes, have favorable advantages with the potential to further improve cancer immunotherapy and even stronger immune responses by improving cell type-specific delivery and enhancing drug efficacy. Liposomes...

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Veröffentlicht in:Pharmaceutics Jg. 12; H. 11; S. 1054
Hauptverfasser: Gu, Zili, Da Silva, Candido, Van der Maaden, Koen, Ossendorp, Ferry, Cruz, Luis
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Switzerland MDPI 04.11.2020
MDPI AG
Schlagworte:
cancer immunotherapy
drug delivery
immunomodulation
liposome
Review
immunomodulation
drug delivery
liposome
cancer immunotherapy
ISSN:1999-4923, 1999-4923
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Zusammenfassung:Cancer immunotherapy has shown remarkable progress in recent years. Nanocarriers, such as liposomes, have favorable advantages with the potential to further improve cancer immunotherapy and even stronger immune responses by improving cell type-specific delivery and enhancing drug efficacy. Liposomes can offer solutions to common problems faced by several cancer immunotherapies, including the following: (1) Vaccination: Liposomes can improve the delivery of antigens and other stimulatory molecules to antigen-presenting cells or T cells; (2) Tumor normalization: Liposomes can deliver drugs selectively to the tumor microenvironment to overcome the immune-suppressive state; (3) Rewiring of tumor signaling: Liposomes can be used for the delivery of specific drugs to specific cell types to correct or modulate pathways to facilitate better anti-tumor immune responses; (4) Combinational therapy: Liposomes are ideal vehicles for the simultaneous delivery of drugs to be combined with other therapies, including chemotherapy, radiotherapy, and phototherapy. In this review, different liposomal systems specifically developed for immunomodulation in cancer are summarized and discussed.
Bibliographie:ObjectType-Article-1
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ObjectType-Review-3
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ISSN:1999-4923
1999-4923
DOI:10.3390/pharmaceutics12111054