Loss of Wnt4 and Foxl2 leads to female-to-male sex reversal extending to germ cells

The discovery that the SRY gene induces male sex in humans and other mammals led to speculation about a possible equivalent for female sex. However, only partial effects have been reported for candidate genes experimentally tested so far. Here we demonstrate that inactivation of two ovarian somatic...

Full description

Saved in:

Bibliographic Details
Published in:	Human molecular genetics Vol. 16; no. 23; p. 2795
Main Authors:	Ottolenghi, Chris, Pelosi, Emanuele, Tran, Joseph, Colombino, Maria, Douglass, Eric, Nedorezov, Timur, Cao, Antonio, Forabosco, Antonino, Schlessinger, David
Format:	Journal Article
Language:	English
Published:	England 01.12.2007
Subjects:	Animals Animals, Newborn Disorders of Sex Development Female Forkhead Box Protein L2 Forkhead Transcription Factors - deficiency Forkhead Transcription Factors - genetics Forkhead Transcription Factors - metabolism Germ Cells - cytology Germ Cells - metabolism Humans Male Mice Mice, Inbred C57BL Mice, Knockout Mice, Transgenic Models, Biological Ovary - cytology Ovary - embryology Pregnancy Sex Determination Processes Sex Differentiation Testis - cytology Testis - embryology Wnt Proteins - deficiency Wnt Proteins - genetics Wnt Proteins - metabolism Wnt4 Protein
ISSN:	0964-6906
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!