Single-Cell Transcriptomics of Pancreatic Cancer Precursors Demonstrates Epithelial and Microenvironmental Heterogeneity as an Early Event in Neoplastic Progression

Early detection of pancreatic ductal adenocarcinoma (PDAC) remains elusive. Precursor lesions of PDAC, specifically intraductal papillary mucinous neoplasms (IPMNs), represent a pathway to invasive neoplasia, although the molecular correlates of progression remain to be fully elucidated. Single-cell...

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Vydáno v:	Clinical cancer research Ročník 25; číslo 7; s. 2194
Hlavní autoři:	Bernard, Vincent, Semaan, Alexander, Huang, Jonathan, San Lucas, F Anthony, Mulu, Feven C, Stephens, Bret M, Guerrero, Paola A, Huang, Yanqing, Zhao, Jun, Kamyabi, Nabiollah, Sen, Subrata, Scheet, Paul A, Taniguchi, Cullen M, Kim, Michael P, Tzeng, Ching-Wei, Katz, Matthew H, Singhi, Aatur D, Maitra, Anirban, Alvarez, Hector A
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 01.04.2019
Témata:	Adenocarcinoma, Mucinous - genetics Carcinoma, Pancreatic Ductal - genetics Disease Progression Humans Pancreatic Neoplasms - genetics Phenotype Tumor Microenvironment
ISSN:	1557-3265, 1557-3265
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